Acute oral toxicity test of chemical compounds in silkworms
| Autor: | Yasuhiko Matsumoto, Satoshi Nishida, Takuro Ueki, Takuya Sugita, Kimihito Usui, Kazuhisa Sekimizu, Hidenobu Okumura |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cytotoxicity test Administration Oral Pharmacology Risk Assessment Median lethal dose Lethal Dose 50 03 medical and health sciences Animal model Species Specificity Toxicity Tests Acute Animals Humans Medicine Pharmacology (medical) Oral toxicity General Pharmacology Toxicology and Pharmaceutics Observer Variation business.industry fungi Reproducibility of Results General Medicine Bombyx 030104 developmental biology Larva Models Animal Toxicity Observer variation business |
| Zdroj: | Drug Discoveries & Therapeutics. 10:57-61 |
| ISSN: | 1881-784X 1881-7831 |
| DOI: | 10.5582/ddt.2016.01025 |
| Popis: | This study performed an acute oral toxicity test of 59 compounds in silkworms. These compounds are listed in OECD guidelines as standard substances for a cytotoxicity test, and median lethal dose (LD(50)) werecalculated for each compound. Acute oral LD(50) values in mammals are listed in OECD guidelines and acute oral LD(50) values in silkworms were determined in this study. R(2) for the correlation between LD(50) values in mammals and LD(50) values in silkworms was 0.66. In addition, the acute oral toxicity test in silkworms was performed by two different facilities, and test results from the facilities were highly reproducible. These findings suggest that an acute oral toxicity test in silkworms is a useful way to evaluate the toxicity of compounds in mammals. |
| Databáze: | OpenAIRE |
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