Poor nutritional status is associated with other geriatric domain impairments and adverse postoperative outcomes in onco-geriatric surgical patients - A multicentre cohort study

Autor: M.G. Huisman, G. Veronese, R.A. Audisio, G. Ugolini, I. Montroni, G.H. de Bock, B.L. van Leeuwen, A. Vigano, L. Gilbert, J. Spiliotis, C. Stabilini, N. de Liguori Carino, E. Farinella, G. Stanojevic, B.T. Veering, M.W. Reed, P.S. Somasundar
Přispěvatelé: Damage and Repair in Cancer Development and Cancer Treatment (DARE), Life Course Epidemiology (LCE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Clinical Cognitive Neuropsychiatry Research Program (CCNP), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Huisman, M.G., Veronese, G., Audisio, R.A., Ugolini, G., Montroni, I., de Bock, G.H., van Leeuwen, B.L., Vigano, A., Gilbert, L., Spiliotis, J., Stabilini, C., de Liguori Carino, N., Farinella, E., Stanojevic, G., Veering, B.T., Reed, M.W., Somasundar, P.S.
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
COLORECTAL-RESECTION
SURGERY
medicine.medical_treatment
Predictive Value of Test
Logistic regression
0302 clinical medicine
Nutritional status
Risk Factors
Weight loss
Neoplasms
SUPPORT
Odds Ratio
Prevalence
Prospective Studies
030212 general & internal medicine
ELDERLY-PATIENTS
Depression (differential diagnoses)
Netherlands
Aged
80 and over
RISK
Rehabilitation
General Medicine
Nutritional Statu
Oncology
030220 oncology & carcinogenesis
Female
medicine.symptom
Human
Cohort study
REHABILITATION
medicine.medical_specialty
Frail Elderly
CANCER-PATIENTS
Risk Assessment
03 medical and health sciences
Postoperative complications
Netherland
INFLAMMATION
Predictive Value of Tests
Internal medicine
medicine
Humans
FRAILTY
Neoplasm Staging
Aged
Performance status
OLDER PATIENTS
business.industry
Risk Factor
Odds ratio
Geriatric assessment
Surgery
R1
United Kingdom
Confidence interval
Postoperative complication
Prospective Studie
Neoplasm
business
Zdroj: European Journal of Surgical Oncology, 42(7), 1009-1017. ELSEVIER SCI LTD
ISSN: 1532-2157
0748-7983
DOI: 10.1016/j.ejso.2016.03.005
Popis: BACKGROUND: Nutritional status (NS), though frequently affected in onco-geriatric patients, is no standard part of a geriatric assessment. The aim of this study was to analyse the association between a preoperatively impaired NS and geriatric domain impairments and adverse postoperative outcomes in onco-geriatric surgical patients.METHODS: 309 patients ≥70 years undergoing surgery for solid tumours were prospectively recruited. Nine screening tools were preoperatively administered as part of a geriatric assessment. NS was based on BMI, weight loss and food intake. Odds ratio's (OR) and 95% confidence intervals (95% CI) were estimated using logistic regression analysis. The occurrence of 30-day adverse postoperative outcomes was recorded.RESULTS: At a median age of 76 years, 107 patients (34.6%) had an impaired NS. Decreased performance status and depression were associated with an impaired NS, when adjusted for tumour characteristics and comorbidities (ORPS>1 3.46; 95% CI 1.56-7.67. ORGDS>5 2.11; 95% CI 1.05-4.26). An impaired NS was an independent predictor for major complications (OR 3.3; 95% CI 1.6-6.8). Ten out of 11 patients who deceased had an impaired NS.CONCLUSION: An impaired NS is prevalent in onco-geriatric patients considered to be fit for surgery. It is associated with decreased performance status and depression. An impaired NS is a predictor for adverse postoperative outcomes. NS should be incorporated in a geriatric assessment.
Databáze: OpenAIRE
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