Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine
| Autor: | Noor Siyam, Moe Tun, Nehad M. Ayoub, Lucia Oton-Gonzalez, Kwangsun Stephen Suh, Niraj Lodhi, Angela Gerona, Arati A. Inamdar, Rana Sandhu, Dainelle Morris, Poonam Nagpal |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty diagnosis precision medicine Review NO 03 medical and health sciences 0302 clinical medicine immune system diseases Internal medicine hemic and lymphatic diseases medicine Adverse effect business.industry DLBCL diagnosis R-CHOP precision medicine prognosis Advanced stage Treatment options Precision medicine medicine.disease Lymphoma Clinical trial 030104 developmental biology R-CHOP 030220 oncology & carcinogenesis DLBCL Molecular targets prognosis business Diffuse large B-cell lymphoma |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Despite the great efforts for better treatment options for diffuse large B-cell lymphoma (DLBCL) (most common form of non-Hodgkin lymphoma, NHL) to treat and prevent relapse, it continues to be a challenge. Here, we present an overview of DLBCL and address the diagnostic assays and molecular techniques used in its diagnosis, role of biomarkers in detection, treatment of early and advanced stage DLBCL, and novel drug regimens. We discuss the significant biomarkers that have emerged as essential tools for stratifying patients according to risk factors and for providing insights into the use of more targeted and individualized therapeutics. We discuss techniques such as gene expression studies, including next-generation sequencing, which have enabled a more understanding of the complex pathogenesis of DLBCL and have helped determine molecular targets for novel therapeutic agents. We examine current treatment approaches, outline the findings of completed clinical trials, and provide updates for ongoing clinical trials. We highlight clinical trials relevant to the significant fraction of DLBCL patients who present with complex cases marked by high relapse rates. Supported by an increased understanding of targetable pathways in DLBCL, clinical trials involving specialized combination therapies are bringing us within reach the promise of an effective cure to DLBCL using precision medicine. Optimization of therapy remains a crucial objective, with the end goal being a balance between high survival rates through targeted and personalized treatment while reducing adverse effects in DLBCL patients of all subsets. |
| Databáze: | OpenAIRE |
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