Predictors of Left Ventricular Function Deterioration in Patients With Left Bundle Branch Block and Ejection Fraction >50%
| Autor: | George O. Angheloiu, Ure Mezu, Samir Saba, Kathy Edelman, Hemal Shah, Melissa Saul |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Heart Ventricles Bundle-Branch Block Population Emergency Nursing Ventricular Function Left Cardiac Resynchronization Therapy Electrocardiography Ventricular Dysfunction Left Internal medicine medicine Humans In patient education Aged Retrospective Studies education.field_of_study Ejection fraction Ventricular function medicine.diagnostic_test business.industry Left bundle branch block Stroke Volume Middle Aged medicine.disease Predictive value Treatment Outcome Echocardiography Heart failure Emergency Medicine Cardiology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Congestive Heart Failure. 19:E1-E4 |
| ISSN: | 1527-5299 |
| Popis: | Resynchronization therapy has become standard of care in patients with left bundle branch block (LBBB), congestive heart failure (CHF), and low ejection fraction (EF). In order to characterize the left ventricular (LV) function evolution in patients with LBBB and baseline preserved LVEF, records of all patients who visited an academic echocardiography laboratory during a period of 4 years were retrospectively investigated. Patients were included if they had a baseline EF >50%, LBBB on surface electrocardiography, and at least one follow-up echocardiogram no earlier than 3 months after the baseline study. The endpoint was the occurrence of EF deterioration to values ≤40%. Clinical variables associated with this outcome were identified. Forty-nine patients satisfied the entry criteria. Over a mean 13±8.5 months of follow-up (range 3 to 36), 8 patients (16%) experienced EF deterioration ≤40%. History of CHF prior to baseline echocardiogram and LV mass >300 g were associated with this phenomenon (P=.004 and P=.015, respectively), with a negative predictive value of 100% and 92%, respectively. Our data profiles a risk-stratification methodology in patients with LBBB and baseline EF >50% and possibly a triage strategy toward resynchronization therapy in this population. |
| Databáze: | OpenAIRE |
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