Correction: A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt
| Autor: | Biruk Yeshitela, Ray Borrow, Marietou Dieng, Brian Greenwood, Babatunji A. Omotara, Awa Traore, Olivier Manigart, Oumarou Djermakoye, James M. Stuart, Aldiouma Diallo, Musa Hassan-King, Helen Findlow, Isaac Osei, Tesfaye Moti Demisse, Ali Elhaji Mahamane, El Hadj Ba, Kanny Diallo, Wude Mihret, Abraham Hodgson, Mamadou B. Coulibaly, Samba O. Sow, Souleymane Doucoure, Maria do Desterro Soares Brandão Nascimento, Arouna Woukeu, Cheikh Sokhna, Serge Alavo, Stephen Laryea Quaye, Jean-François Jusot, Rahamatou Moustapha Boukary, Daniel Chandramohan, Abraham Aseffa, Jean-Marc Collard, Caroline Trotter, Doumagoum M. Daugla |
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| Přispěvatelé: | Trotter, Caroline [0000-0003-4000-2708], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Adolescent 030106 microbiology lcsh:Medicine Enzyme-Linked Immunosorbent Assay Meningococcal Vaccines 32 Biomedical and Clinical Sciences Meningitis Meningococcal Neisseria meningitidis Serogroup 03 medical and health sciences 0302 clinical medicine Seroepidemiologic Studies Correct name Humans Medicine 030212 general & internal medicine Child Epidemics lcsh:Science 3202 Clinical Sciences Aged Multidisciplinary business.industry Vaccination lcsh:R Correction Infant Middle Aged Antibodies Bacterial Virology Cross-Sectional Studies Child Preschool Immunoglobulin G Africa Carrier State Female lcsh:Q African meningitis belt business Immunologic Memory |
| Zdroj: | PLoS ONE, Vol 11, Iss 7, p e0158938 (2016) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | The pattern of epidemic meningococcal disease in the African meningitis belt may be influenced by the background level of population immunity but this has been measured infrequently. A standardised enzyme-linked immunosorbent assay (ELISA) for measuring meningococcal serogroup A IgG antibodies was established at five centres within the meningitis belt. Antibody concentrations were then measured in 3930 individuals stratified by age and residence from six countries. Seroprevalence by age was used in a catalytic model to determine the force of infection. Meningococcal serogroup A IgG antibody concentrations were high in each country but showed heterogeneity across the meningitis belt. The geometric mean concentration (GMC) was highest in Ghana (9.09 μg/mL [95% CI 8.29, 9.97]) and lowest in Ethiopia (1.43 μg/mL [95% CI 1.31, 1.57]) on the margins of the belt. The force of infection was lowest in Ethiopia (λ = 0.028). Variables associated with a concentration above the putative protective level of 2 μg/mL were age, urban residence and a history of recent vaccination with a meningococcal vaccine. Prior to vaccination with the serogroup A meningococcal conjugate vaccine, meningococcal serogroup A IgG antibody concentrations were high across the African meningitis belt and yet the region remained susceptible to epidemics. |
| Databáze: | OpenAIRE |
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