Effect of fluid forcing on vestibular hair bundles
| Autor: | Jong-Hoon Nam, John R. Cotton, J. W. Grant |
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| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1878-6464 0957-4271 |
| DOI: | 10.3233/ves-2005-155-604 |
| Popis: | A dynamic 3-D hair bundle model including inertia and viscous fluid drag effects based on the finite element method is presented. Six structural components are used to construct the hair bundle – kinocilium, stereocilia, upper lateral links, shaft links, tip links, and kinocilial links. Fluid drag is distributed on the surface of cilia columns. Bundle mechanics are analyzed under two distinct loading conditions: (1) drag caused by the shear flow of the surrounding endolymph fluid (fluid-forced), (2) a single force applied to the tip of the kinocilium (point-forced). A striolar and a medial extrastriolar vestibular hair cell from the utricle of a turtle are simulated. The striolar cell bundle shows a clear difference in tip link tension profile between fluid-forced and point-forced cases. When the striolar cell is fluid forced, it shows more evenly distributed tip link tensions and is far more sensitive, responding like an on/off switch. The extrastriolar cell does not show noticeable differences between the forcing types. For both forcing conditions, the extrastriolar cell responds serially – the nearest tip links to the kinocilium get tensed first, then the tension propagates to the farther tip links. |
| Databáze: | OpenAIRE |
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