Light-chain deposition disease of the kidney: a case report
| Autor: | R. Goucha, Hédi Ben Maiz, Mohamed Habib Jaafoura, A. Kheder, Sihem Darouich, Semy Zekri |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Nephrotic Syndrome Biopsy Plasma cell dyscrasia Fluorescent Antibody Technique Kidney Light chain deposition disease Pathology and Forensic Medicine Microscopy Electron Transmission Structural Biology Glomerulopathy medicine Humans Microhematuria medicine.diagnostic_test business.industry medicine.disease medicine.icd_9_cm_classification Bone marrow examination medicine.anatomical_structure Immunoglobulin Light Chains Renal biopsy business Nephrotic syndrome |
| Zdroj: | Ultrastructural pathology. 36(2) |
| ISSN: | 1521-0758 |
| Popis: | A 41-year-old man was admitted for evaluation of nephrotic syndrome associated with microhematuria, hypertension, and moderate renal failure. In serum and urine samples, monoclonal IgG-lambda was detected. Bone marrow examination showed normal representation of all cell lines with normal range of plasma cells. Renal biopsy demonstrated diabetes-like nodular glomerulosclerosis. Immunofluorescence failed to demonstrate the presence of kappa or lambda light chains in the kidney. Electron microcopy showed granular electron-dense deposits along the glomerular basement membranes and in the mesangial nodules. The patient was diagnosed as having light-chain deposition disease (LCDD) without evidence of plasma cell dyscrasia. This report was designed to stress the significant challenges that remain in the diagnosis of LCDD-related glomerulopathy. The salient morphological features that help in making an accurate diagnosis are discussed. |
| Databáze: | OpenAIRE |
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