The isolation of a fungal metabolite which exhibits antimicrobial synergy with sterigmatocystin
| Autor: | M.W. Adlard, G. Holt, M.J. Perry |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Aflatoxin
Sterigmatocystin Gram-positive bacteria Metabolite Applied Microbiology and Biotechnology Microbiology Aspergillus nidulans Fungal Proteins Structure-Activity Relationship chemistry.chemical_compound Moiety Glycoproteins chemistry.chemical_classification biology fungi Drug Synergism Antimicrobial biology.organism_classification Anti-Bacterial Agents Xanthenes chemistry Biochemistry Glycoprotein Bacillus subtilis |
| Zdroj: | Journal of Applied Bacteriology. 52:83-89 |
| ISSN: | 0021-8847 |
| DOI: | 10.1111/j.1365-2672.1982.tb04376.x |
| Popis: | A metabolite, which acted synergistically with sterigmatocystin to inhibit the growth of several Gram positive bacteria, has been isolated from several strains of Aspergillus nidulans. Preliminary characterization of this metabolite indicated that it was a high-molecular-weight glycoprotein. Dihydrosterigmatocystin, aflatoxin B, and aflatoxin Gt all failed to exhibit antimicrobial synergy with the glycoprotein. Thus, the synergy with the glycoprotein was specific for sterigmatocystin and the presence of the unsaturated bifuran moiety was shown to be essential to the antimicrobial action of the synergy. |
| Databáze: | OpenAIRE |
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