I-131 doping of silver nanoparticles platform for tumor theranosis guided drug delivery
| Autor: | Tamer M. Sakr, Mohamed M. Swidan, M. T. El-Kolaly, M. A. Motaleb, Omneya Mohammed Khowessah, A. Abd El-Bary |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Biodistribution Silver Theranostic Nanomedicine Cell Survival Metal Nanoparticles Pharmaceutical Science Nanoparticle 02 engineering and technology Polyethylene glycol 010403 inorganic & nuclear chemistry 01 natural sciences Silver nanoparticle Cell Line Iodine Radioisotopes Mice chemistry.chemical_compound Drug Delivery Systems Drug Stability Zeta potential Animals Humans Tissue Distribution Chemistry technology industry and agriculture Sarcoma 021001 nanoscience & nanotechnology 0104 chemical sciences Drug Liberation Drug delivery 0210 nano-technology Drug carrier Nuclear chemistry |
| Zdroj: | European Journal of Pharmaceutical Sciences. 122:239-245 |
| ISSN: | 0928-0987 |
| Popis: | Nanotechnology may be applied in medicine where the utilization of nanoparticles (≤100 nm) for the delivery and targeting of theranostic agents is at the forefront of projects in cancer nano-science. This study points a novel one step synthesis approach to build up polyethylene glycol capped silver nanoparticles doped with I-131 radionuclide (131I-doped Ag-PEG NPs). The formula was prepared with average hydrodynamic size 21 nm, zeta potential - 25 mV, radiolabeling yield 98 ± 0.76%, and showed good in-vitro stability in saline and mice serum. The in-vitro cytotoxicity study of cold Ag-PEG NPs formula as a drug carrier vehicle showed no cytotoxic effect on normal cells (WI-38 cells) at a concentration below 3 μL/104 cells. The in-vivo biodistribution pattern of 131I-doped Ag-PEG NPs in solid tumor bearing mice showed high radioactivity accumulation in tumor tissues with maximum uptake of 35.43 ± 1.12 and 63.8 ± 1.3% ID/g at 60 and 15 min post intravenous (I.V.) and intratumoral injection (I.T.), respectively. Great potential of T/NT ratios were obtained throughout the experimental time points with maximum ratios 45.23 ± 0.65 and 92.46 ± 1.02 at 60 and 15 min post I.V. and I.T. injection, respectively. Thus, 131I-doped Ag-PEG NPs formulation could be displayed as a great potential tumor nano-sized theranostic probe. |
| Databáze: | OpenAIRE |
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