Limited efficacy of experimental anti-epileptic drugs in refractory temporal lobe epilepsy: Implications for patient management and study recruitment

Autor:	William T. Couldwell, Adrian L. Rabinowicz, Carlton W. Henderson, Christopher M. DeGiorgio
Jazyk:	angličtina
Předmět:	medicine.medical_specialty Referral Drug Resistance Clinical Neurology Electroencephalography behavioral disciplines and activities Temporal lobe Epilepsy Refractory Double-Blind Method Internal medicine medicine Combined Modality Therapy Humans temporal lobectomy Randomized Controlled Trials as Topic Patient Care Team medicine.diagnostic_test business.industry General Medicine Drugs Investigational temporal lobe epilepsy medicine.disease anti-epileptic drugs Temporal Lobe Surgery Patient management Psychosurgery nervous system diseases Treatment Outcome Epilepsy Temporal Lobe Neurology nervous system Anticonvulsants Neurology (clinical) business psychological phenomena and processes
Zdroj:	Seizure. (2):135-138
ISSN:	1059-1311
DOI:	10.1016/S1059-1311(95)80093-X
Popis:	Patients with refractory temporal lobe epilepsy (TLE) are commonly recruited for investigational anti-epileptic drug (XAED) studies. However, the long-term outcome of TLE after exposure to XAEDs is poorly documented. In this pilot study, we report the USC Epilepsy Center's experience of 19 patients with TLE enrolled in three XAED trials. The data reinforce that TLE is a drug-resistent epilepsy, and referral of good surgical candidates for surgery rather than XAED trials is more likely to result in remission.
Databáze:	OpenAIRE
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