The role of taurine in the survival and function of cerebellar cells in cultures of early postnatal cat
| Autor: | E. Trenkner, J.A. Sturman |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Cell type Cerebellum Taurine Cell Survival Glutamic Acid Cell Count Biology Kitten chemistry.chemical_compound Glutamates Developmental Neuroscience Internal medicine biology.animal medicine Animals Neurons CATS Endocrinology medicine.anatomical_structure Animals Newborn chemistry Cell culture Immunology Cats beta-Alanine Neuroglia Neuron Developmental Biology |
| Zdroj: | International Journal of Developmental Neuroscience. 9:77-83 |
| ISSN: | 1873-474X 0736-5748 |
| DOI: | 10.1016/0736-5748(91)90075-w |
| Popis: | The role of taurine and β-alanine was analyzed in kitten cerebellar cultures. Since in contrast to mouse, cats (and primates including man) cannot synthesize sufficient taurine to maintain their body pools, we considered the cat an ideal species for the analysis of the role of taurine during early postnatal cerebellar development under controlled conditions. Unexpectedly, we found that the presence of taurine was toxic to neurons but that compounds, considered to be competitors for the β-amino acid uptake system, support cell survival and cell function in vitro, the opposite of the results found in mice. This could be explained by the finding that only minute amounts of [3H]taurine were taken up by both cat neurons and glial cells under optimal culture conditions but that in the presence of the taurine analogues β-alanine and guanidinoethane sulfonic acid (GES) significant amounts of taurine were found in all cell types. These differences between mouse cerebellar cells and cat cerebellar cells in vitro suggest that a reevaluation of the mechanisms that control taurine function in cats and primates is warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text