Does seasonal allergic rhinitis increase sensitivity to ammonia exposure?
| Autor: | Klaus Golka, Meinolf Blaszkewicz, Christoph van Thriel, Stefan Kleinbeck, Michael Schäper, Marlene Pacharra |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Allergy Substance P Nitric Oxide medicine.disease_cause Allergic inflammation Young Adult 03 medical and health sciences 0302 clinical medicine Ammonia medicine Humans 030212 general & internal medicine Occupational exposure limit HMGB1 Protein 030223 otorhinolaryngology Sensitization Air Pollutants Blinking medicine.diagnostic_test Tumor Necrosis Factor-alpha Chemistry Public Health Environmental and Occupational Health Rhinitis Allergic Seasonal Environmental Exposure Immunoglobulin E Nasal Lavage Fluid medicine.disease medicine.anatomical_structure Exhaled nitric oxide Immunology Irritants Female Rhinomanometry Irritation |
| Zdroj: | International Journal of Hygiene and Environmental Health. 220:840-848 |
| ISSN: | 1438-4639 |
| DOI: | 10.1016/j.ijheh.2017.03.013 |
| Popis: | Allergic inflammation in the upper airways represents a wide-spread health issue: Little is known about whether it increases sensitivity to airborne chemicals thereby challenging established exposure limits that neglect such differences in susceptibility. To investigate the role of pre-existing allergic inflammation, 19 subjects with seasonal allergic rhinitis (SAR) and 18 control subjects with low risk of sensitization were exposed for 4h to ammonia in two concentrations (cross-over design): 2.5ppm (odor threshold) and 0-40ppm (occupational exposure limit: 20ppm TWA). Prior to the whole-body exposure, it was confirmed that subjects with SAR showed persistent inflammation outside the pollen season as indicated by increased exhaled nitric oxide and total immunoglobulin E in serum compared to controls. Despite concentration-dependent increases in chemosensory perceptions and acute symptoms, SAR status did not modulate subjective effects of exposure. Moreover, SAR status did not affect the investigated physiological endpoints of sensory irritation: While eye-blink recordings confirmed weak ocular irritation properties of ammonia at 0-40ppm, this effect was not enhanced in SAR subjects compared to controls. Irrespective of SAR status, exposure to 0-40ppm ammonia did not result in a cortisol stress response, objective nasal obstruction as measured with anterior active rhinomanometry, or an inflammatory response as indexed by substance P, tumor-necrosis-factor α, and high-mobility-group protein 1 in nasal lavage fluid. At least for the malodorous compound ammonia, these results do not support the hypothesis that SAR enhances chemosensory effects in response to local irritants. Before generalizing this finding, more compounds as well as sensitization to perennial allergens need to be investigated. |
| Databáze: | OpenAIRE |
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