Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction
| Autor: | Hannes Noack, Jonas Hornung, Vanessa Nieratschker, Mara Thomas, Birgit Derntl, Jessica Freiherr, Gisbert Farger |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotype media_common.quotation_subject Emotions Olfaction Luteal Phase Audiology Receptors Odorant Affect (psychology) 050105 experimental psychology Young Adult 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Endocrinology Humans Medicine Testosterone 0501 psychology and cognitive sciences Progesterone Menstrual cycle media_common Psychological Tests Sex Characteristics Estradiol Endocrine and Autonomic Systems business.industry 05 social sciences Androstadienone Bayes Theorem Cognition Androstadienes Smell Affect Mood chemistry Female Gene-Environment Interaction business 030217 neurology & neurosurgery Stroop effect Sex characteristics |
| Zdroj: | Hormones and Behavior. 98:45-54 |
| ISSN: | 0018-506X |
| DOI: | 10.1016/j.yhbeh.2017.12.003 |
| Popis: | The androgen derivative androstadienone (AND) is present in human sweat and may act as human chemosignal. Though effects of AND have been reported with respect to emotional and cognitive processes, results have been highly inconsistent. For this reason, it is likely that AND-action is dependent on modulatory factors. Here we wanted to specifically investigate the impact of genotypic variations of the AND-receptor OR7D4, as well as the influence of participant sex and concomitant hormonal fluctuations on AND-action during emotional interference processing, olfactory performance and mood assessments. To this end 80 healthy individuals (women taking oral contraceptives; naturally cycling women measured during the luteal phase and men) were tested twice on two consecutive days (AND vs. placebo exposure) with an emotional Stroop task. Also, olfactory performance and mood was assessed. Participants provided saliva samples to measure testosterone, progesterone and estradiol and a blood sample to assess genotypic variations of the AND-receptor OR7D4. We found a small task-dependent reduction of overall error rates under AND but no modulation of effects by genetic variation or group (female OC, female NC, male) with respect to olfactory performance and mood. Additional analyses with help of Bayesian statistics gave strong evidence in favor of specific null hypotheses suggesting that the action of AND was not modulated by either genotypic variations or sex of participants with respect to interference control (bias indices), olfactory self-reports and mood parameters. Additional effects of AND in connection with hormonal fluctuations are reported. |
| Databáze: | OpenAIRE |
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