Drugs which influence serotonin transporter and serotonergic receptors: Pharmacological and clinical properties in the treatment of depression
| Autor: | Aleksander P. Mazurek, Natalia Lysenko, Przemyslaw Taciak |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology Serotonergic 03 medical and health sciences 0302 clinical medicine Monoaminergic medicine Animals Humans Adverse effect Serotonin transporter Depressive Disorder Major biology Brain General Medicine medicine.disease Antidepressive Agents Affect 030104 developmental biology Sexual dysfunction Treatment Outcome Mechanism of action biology.protein Major depressive disorder Serotonin Serotonin Antagonists medicine.symptom Psychology 030217 neurology & neurosurgery Selective Serotonin Reuptake Inhibitors |
| Zdroj: | Pharmacological reports : PR. 70(1) |
| ISSN: | 2299-5684 |
| Popis: | Depression is nowadays a major contributor to global burden of disease. The most commonly prescribed drugs influence monoaminergic pathways, mainly concentrating on serotonin. Unfortunately, there are several drawbacks associated with these drugs, namely late onset of action, risk of suicide and adverse effects: mainly nausea, vomiting and sexual dysfunction. Therefore there is still need for new drugs with possibly high efficacy and fewer side effects. In this paper selected compounds which inhibit serotonin reuptake by acting on the serotonin transporter (SERT) and various serotoninergic receptors are presented. We also discuss the ways in which their mechanism of action can be modified to improve pharmacological profile. Here, we focus on describing drugs' potency, efficacy and adverse effects. Additional applications, apart from depression, are also discussed. |
| Databáze: | OpenAIRE |
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