An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women
| Autor: | Ahmet Sivas, Serdar Öztezcan, Müjdat Uysal, Umit Mutlu-Turkoglu, Aysegul Telci, Yusuf Orhan, Gülçin Aykaç-Toker |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Lipid Peroxides medicine.medical_specialty Antioxidant Apolipoprotein B Arteriosclerosis medicine.medical_treatment Statistics as Topic General Biochemistry Genetics and Molecular Biology Body Mass Index Lipid peroxidation chemistry.chemical_compound Risk Factors Malondialdehyde Internal medicine Blood plasma medicine Humans Obesity Lipoprotein oxidation biology Chemistry Antibody titer General Medicine Middle Aged Lipoproteins LDL Cholesterol Endocrinology biology.protein Female lipids (amino acids peptides and proteins) Oxidation-Reduction Lipoprotein |
| Zdroj: | Clinical and Experimental Medicine. 2:171-174 |
| ISSN: | 1591-9528 1591-8890 |
| Popis: | Endogenous malondialdehyde and diene conjugate levels, the susceptibility of apolipoprotein B-containing lipoproteins to copper-induced lipid peroxidation, and antibody titer against oxidized low-density lipoproteins were increased, but serum antioxidant activity was unchanged in obese women. Serum cholesterol, low-density lipoproteincholesterol, and trigliceride levels were also elevated, but high-density lipoprotein-cholesterol levels remained unchanged in obese women. In vitro, oxidation of apolipoprotein B-containing lipoproteins and levels of antibody against oxidized low-density lipoprotein correlated with body mass index, serum total cholesterol, and low-density lipoproteincholesterol levels in obese women. These results indicate that obesity is associated with increases in endogenous lipid peroxides, oxidation of low-density lipoproteins, and lipids in serum. |
| Databáze: | OpenAIRE |
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