Insight and regional brain volumes in schizophrenia
| Autor: | Cláudio Campi de Castro, Geraldo F. Busatto, Mario Rodrigues Louzã Neto, Débora Pastore Bassitt |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Adolescent Prefrontal Cortex Frontal lobe atrophy computer.software_genre behavioral disciplines and activities White matter Voxel mental disorders medicine Humans Pharmacology (medical) In patient Biological Psychiatry Psychiatric Status Rating Scales medicine.diagnostic_test Brain Magnetic resonance imaging General Medicine Awareness Middle Aged medicine.disease Magnetic Resonance Imaging Self Concept Psychiatry and Mental health medicine.anatomical_structure Schizophrenia Psychiatric status rating scales Impaired insight Female Psychology Neuroscience computer |
| Zdroj: | European archives of psychiatry and clinical neuroscience. 257(1) |
| ISSN: | 0940-1334 |
| Popis: | We have investigated the relationship between insight impairment and regional brain volumes (gray and white matter) in schizophrenia using voxel-based morphometry (VBM). Fifty patients with schizophrenia were evaluated using the Scale for Unawareness of Mental Disorders. Magnetic resonance images were acquired, segmented and spatially normalized using optimized VBM routines. No significant inverse correlations were detected between insight impairment and gray or white matter volumes in the prefrontal region (where significant findings had been predicted a priori), or in any other brain areas. Our results do not support previous hypotheses suggesting a relationship between frontal lobe atrophy and impaired insight in patients with schizophrenia. |
| Databáze: | OpenAIRE |
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