Short Communication: Diversity of TNF-α region in Chinese domestic goats
| Autor: | G.X. E, R.S. Na, Y.J. Zhao, Y.H. Ma, Y.F. Huang |
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| Rok vydání: | 2015 |
| Předmět: |
Untranslated region
Linkage disequilibrium China Genotype medicine.medical_treatment Major histocompatibility complex Polymorphism Single Nucleotide Linkage Disequilibrium Exon Gene Frequency Genetics medicine Animals Molecular Biology Allele frequency 3' Untranslated Regions biology Geography Three prime untranslated region Tumor Necrosis Factor-alpha Goats Genetic Variation General Medicine Cytokine biology.protein Tumor necrosis factor alpha |
| Zdroj: | Genetics and molecular research : GMR. 14(2) |
| ISSN: | 1676-5680 |
| Popis: | Tumor necrosis factor-α is a cytokine with a wide range of effects on both lymphoid and non-lymphoid cells. In this study, we identified polymorphisms in major histocompatibility complex class III gene in the 4th exon and the 3' untranslated region of tumor necrosis factor-α to evaluate the immunogenetic diversity of Chinese south indigenous goat. Three single-nucleotide polymorphisms were identified and showed similar frequencies in different except MI loci. These data suggest that the high immunodiversity of the tumor necrosis factor-α region within these breeds can be used for strengthening variety improvement and promoting animal husbandry development in Chinese indigenous goats. |
| Databáze: | OpenAIRE |
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