The predictive value of insulin-like growth factor 1 in irradiation-dependent growth hormone deficiency in childhood cancer survivors
| Autor: | Enrico Clarke, Assunta Albanese, Alessandro Cattoni |
|---|---|
| Přispěvatelé: | Cattoni, A, Clarke, E, Albanese, A |
| Rok vydání: | 2019 |
| Předmět: |
Male
Insulin-like growth factor 1 medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Childhood cancer 030209 endocrinology & metabolism Growth Hypopituitarism Gastroenterology Growth hormone deficiency Young Adult 03 medical and health sciences Insulin-like growth factor 0302 clinical medicine Endocrinology Cancer Survivors 030225 pediatrics Internal medicine medicine Humans Insulin-Like Growth Factor I Young adult Human Growth Hormone business.industry medicine.disease Predictive value Pediatrics Perinatology and Child Health Cohort Neoplasm Female Survivor Cranial Irradiation business Human Hormone |
| Zdroj: | Yearbook of Paediatric Endocrinology. |
| ISSN: | 1662-4009 |
| Popis: | Background: The literature contains conflicting reports on the value of low insulin-like growth factor 1 (IGF-1) levels in predicting radiation-induced growth hormone (GH) deficiency (GHD) in childhood cancer survivors (CCS). These reports often involve small samples of patients who have received irradiation or mixed cohorts including non-irradiated subjects. Objective: We undertook an analysis of the predictive value of low IGF-1 in CCS at risk for GHD after cranial radiotherapy involving the hypothalamic-pituitary (HP) area in a large single-centre cohort. Methods: We performed a retrospective analysis on 158 CCS diagnosed with GHD between January 1, 2003 and October 31, 2017 and identified 117 patients who received radiation for tumours not direct ly involving the HP area. Results: In this cohort, IGF-1 levels p = 0.0023) and had a higher sensitivity (45.6%) among patients with severe GHD. At final height reassessment, IGF-1 Conclusions: IGF-1 levels |
| Databáze: | OpenAIRE |
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