Recurrent thrombosis in antiphospholipid syndrome may be associated with cardiovascular risk factors and inflammatory response
| Autor: | Marina Pereira Collela, Joyce Annichino-Bizzachi, Bruna M Mazetto, Erich Vinicius De Paula, Fernanda Andrade Orsi, Sabrina da Silva Saraiva, Isadora Custódio, Simone Appenzeller |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Autoimmunity Gastroenterology Cohort Studies Monocytosis Antiphospholipid syndrome Recurrence Risk Factors Internal medicine medicine Humans Retrospective Studies Autoimmune disease Inflammation business.industry Autoantibody Retrospective cohort study Thrombosis Hematology medicine.disease Antiphospholipid Syndrome Cardiovascular Diseases Cohort Immunology Female business Cohort study |
| Zdroj: | Thrombosis research. 136(6) |
| ISSN: | 1879-2472 |
| Popis: | Introduction Antiphospholipid syndrome (APS) is a pro-thrombotic autoimmune disease that affects different vascular beds, with potential risk for recurrence. Systemic lupus erythematosus (SLE), specific autoantibodies profile and atherogenic disorders have been described as risk factors for the occurrence of first thrombosis in patients with antiphospholipid antibodies (aPL). However, factors associated with recurrent thrombosis have not yet been completely elucidated in APS. The aim of this study was to evaluate the association of recurrent thrombosis with markers of inflammation, autoimmunity and the presence of atherogenic disorders in APS patients. Materials and methods We performed a retrospective evaluation of a cohort of APS patients in order to determine if markers of inflammation, autoimmunity and cardiovascular risk were associated with recurrence of thrombosis. Results One hundred fifteen patients with APS were included, 60% had primary APS. History of recurrent thrombosis was positive in 38.3% of patients, and 40% of them were on oral anticoagulants at the time of recurrence. Independent risk factors associated with recurrent thrombosis were arterial hypertension (OR = 3.7, 95% CI = 1.6–8.5, P = 0.002) and monocytosis above 500 u/mm 3 (OR = 2.4, 95% CI = 1.2–5.3, P = 0.02). These factors were particularly relevant in cases of venous index event. Conclusion The results suggest that arterial hypertension and monocyte counts may be independent factors for thrombosis recurrence in APS. Given the morbidity of recurrent cases, the results may support the evaluation of therapeutic measures to a rigid control of blood pressures and modulation of inflammatory response in APS, as additional prophylaxis against the recurrence of vascular events. |
| Databáze: | OpenAIRE |
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