Low serum fatty acid levels in pregnancies with fetal gastroschisis: A prospective study
| Autor: | Sandra F Centofanti, Rui Curi, Sonia Tucunduva Phillippi, Rossana Pulcineli Vieira Francisco, Inar Alves de Castro, Maria de Lourdes Brizot, Mara Sandra Hoshida |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Adolescent Physiology Gestational Age Disease 030105 genetics & heredity Pathogenesis Young Adult 03 medical and health sciences Pregnancy GRAVIDEZ Genetics Humans Metabolomics Medicine Prospective cohort study reproductive and urinary physiology Genetics (clinical) Gastroschisis chemistry.chemical_classification Fetus business.industry Abdominal wall defect Fatty Acids Fatty acid medicine.disease Lipids 030104 developmental biology chemistry Case-Control Studies Metabolome Female business Biomarkers |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1552-4833 1552-4825 |
| DOI: | 10.1002/ajmg.a.38638 |
| Popis: | Fetal gastroschisis is a paraumbilical abdominal wall defect with herniation of abdominal organs. The underlying cause of the disease remains unknown; however, studies suggest that nutritional factors may play a role in its development. This prospective case-control study explored the association of serum fatty acid levels of pregnant women and occurrence of gastroschisis. Gastroschisis group comprised 57 pregnant women with fetuses with gastroschisis, and the control group comprised 114 pregnant women with normal fetuses. Serum fatty acids levels were compared between the groups for the overall pregnancy at34 weeks; ≤25 weeks, and25 and34 weeks; and at delivery. Total fatty acids (p = .008), unsaturated fatty acids (p = .002), and the C18:1n9/C18:00 ratio (p = .021) were lower in the gastroschisis group than in the control group during the overall pregnancy; however, the C16:00/C18:2n6 ratio (p = .018) was higher in the gastroschisis group than in the control group during the same period. Total fatty acids (p = .044) and unsaturated fatty acids (p = .024) were lower in the gastroschisis group at ≤25 weeks, and unsaturated fatty acid (p = .025) and the C18:1n9/C18:00 ratio (p = .013) were lower in the gastroschisis group than in the control group at25 and34 weeks. Pregnant women with fetuses with gastroschisis have low serum fatty acids levels during pregnancy. These findings suggest that fatty acids levels may be involved in the pathogenesis of fetal gastroschisis. |
| Databáze: | OpenAIRE |
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