Effect of selenium on sheep lymphocyte responses to mitogens
| Autor: | Knut Moksnes, H.J. Larsen, Gunnar Øvernes |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Lymphocyte medicine.medical_treatment chemistry.chemical_element chemical and pharmacologic phenomena Lymphocyte Activation Selenious Acid Selenium Basal (phylogenetics) Lectins Internal medicine medicine Animals Selenomethionine Phytohaemagglutinin Sheep General Veterinary biology Chemistry Pokeweed mitogen Vitamin E medicine.anatomical_structure Endocrinology Concanavalin A Immunology biology.protein Female |
| Zdroj: | Research in Veterinary Science. 45:11-15 |
| ISSN: | 0034-5288 |
| Popis: | The effect of selenium (Se) on sheep lymphocyte response to mitogens was studied. In an indoor experiment lambs were fed a basal diet containing 0.13 mg Se kg-1, and supplemented with, respectively, 0.1 or 0.5 mg Se kg-1, either as sodium selenite or as selenomethionine. Enhancement of the proliferative response of lymphocytes to phytohaemagglutinin (PHA), pokeweed mitogen (PWM) and concanavalin A was found in lambs following selenium supplementation at the lower levels. The highest dietary selenium content, however, induced decreased mitogen response. Transient increases in lymphocyte response to PHA and PWM by ewes supplemented with selenium was demonstrated in one field study and a combined effect of selenium and vitamin E was seen in another. There was no stimulatory effect on the mitogen response of lymphocytes from sheep supplemented with dietary vitamin E alone. |
| Databáze: | OpenAIRE |
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