Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction
| Autor: | Victor A. Ruthig, Yasuhiro Yamauchi, Michael J. Mitchell, Eglė A. Ortega, Monika A. Ward, Jonathan M. Riel |
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| Přispěvatelé: | Génétique Médicale et Génomique Fonctionnelle (GMGF), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine X Chromosome Reproductive Techniques Assisted media_common.quotation_subject Eukaryotic Initiation Factor-2 Male sex determination Gene Dosage Mice Transgenic Haploidy Biology Y chromosome Gene dosage Article Mice 03 medical and health sciences Genes Y-Linked 0302 clinical medicine Y Chromosome Homologous chromosome Animals Spermatogenesis Gene media_common Genetics Multidisciplinary SOX9 Transcription Factor Sex-Determining Region Y Protein Spermatogonia 030104 developmental biology Testis determining factor [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics Female Ploidy Reproduction 030217 neurology & neurosurgery |
| Zdroj: | Science Science, 2016, 351 (6272), pp.514-516. ⟨10.1126/science.aad1795⟩ Science, American Association for the Advancement of Science, 2016, 351 (6272), pp.514-516. ⟨10.1126/science.aad1795⟩ |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.aad1795 |
| Popis: | Replacing the Y chromosome The mammalian Y chromosome encodes a specialized set of genes that are essential for male viability and fertility. In particular, the sex-determining region Y (SRY) protein is necessary to initiate male sex determination. However, Yamauchi et al. show that the functions of the entire Y chromosome can be replaced with only two genes. In mice, two transgenes, Sox9 and Eif2s3x , compensated for the absence of all Y chromosome genes to allow successful sperm formation. Science , this issue p. 514 |
| Databáze: | OpenAIRE |
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