Immunocytochemical mapping of noradrenergic projections to the rat spinal cord with an antiserum against noradrenaline
| Autor: | F. Sandillon, Michel Geffard, L. Marlier, Alain Privat, N. Rajaofetra, J. L. Ridet, P. Poulat |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Histology Central nervous system Immunocytochemistry Biology Immunoenzyme Techniques Synapse Norepinephrine Nerve Fibers medicine Animals Motor Neurons Nerve Endings General Neuroscience Rats Inbred Strains Dendrites Cell Biology Anatomy Spinal cord Axons Rats Microscopy Electron medicine.anatomical_structure Nociception Spinal Cord Synapses Ultrastructure Locus coeruleus Neuroscience medicine.drug |
| Zdroj: | Journal of Neurocytology. 21:481-494 |
| ISSN: | 1573-7381 0300-4864 |
| DOI: | 10.1007/bf01186952 |
| Popis: | The mapping of noradrenergic innervation was performed in transverse and longitudinal sections of the adult rat spinal cord using noradrenaline immunocytochemistry. Noradrenergic fibres and terminals were distributed in the dorsal horn (mainly in the superficial part), in the vicinity of the different groups of motoneurons, and concentrated in the intermediolateral cell column and around the central canal. The ultrastructural study showed principally axodendritic synapses in the ventral horn and in the intermediolateral cell column. Fewer axosomatic synapses were detected. In the dorsal horn, noradrenaline-innervation was predominantly non-synaptic. It is hypothesized that the noradrenergic modulation of nociception is not mediated through classical synapses. The concept of 'volume transmission' can explain such an influence. Conversely, noradrenaline may be involved in the control of locomotion and automatic functions through conventional synapses. |
| Databáze: | OpenAIRE |
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