A Novel Resistant Maltodextrin Alters Gastrointestinal Tolerance Factors, Fecal Characteristics, and Fecal Microbiota in Healthy Adult Humans
| Autor: | Kazuhiro Ohkuma, Lisa K. Karr-Lilienthal, Nathaniel D. Fastinger, George C. Fahey, Sumiko Kanahori, Krista E. Zinn, Julie K. Spears, Dennis T. Gordon, Kelly S. Swanson, Gerardo M. Nava |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
DNA Bacterial Male Clostridium perfringens medicine.medical_treatment Medicine (miscellaneous) Polymerase Chain Reaction Feces chemistry.chemical_compound Double-Blind Method Ammonia Polysaccharides RNA Ribosomal 16S medicine Humans Food science Bifidobacterium Nutrition and Dietetics biology Prebiotic food and beverages Carbohydrate Fatty Acids Volatile biology.organism_classification Maltodextrin Gastrointestinal Tract Lactobacillus chemistry Resistant maltodextrin Electrophoresis Polyacrylamide Gel Female Fermentation Digestion |
| Zdroj: | Journal of the American College of Nutrition. 27:356-366 |
| ISSN: | 1541-1087 0731-5724 |
| DOI: | 10.1080/07315724.2008.10719712 |
| Popis: | Resistant maltodextrin has been shown to increase fecal bulk by resisting digestion and being partially fermented by colonic bacteria to short-chain fatty acids (SCFA). The objective of this experiment was to determine potential prebiotic effects, gastrointestinal tolerance, and fecal characteristics of free-living humans fed a novel resistant maltodextrin or a normal maltodextrin control.Subjects (n = 38) were enrolled in a randomized, double-blind study where they were assigned to one of three daily treatments: 15 g maltodextrin; 7.5 g maltodextrin plus 7.5 g resistant maltodextrin (Fibersol-2; Matsutani Chemical Company, Hyogo, Japan); and 15 g resistant maltodextrin. The experiment lasted 7 wk and consisted of a 2 wk baseline period, a 3 wk treatment period, and a 2 wk washout period. During wk 3 to 5 (treatment period), subjects consumed their assigned treatments.Resistant maltodextrin supplementation tended to increase (p = 0.12) fecal Bifidobacterium populations during the treatment period, altered (p0.05) bacterial populations from baseline to treatment, and resulted in very minor effects in gastrointestinal tolerance. There was a shift (p0.05) in molar proportions of SCFA towards butyrate, the preferred energy substrate of colonocytes.Resistant maltodextrin supplementation was well tolerated, resulted in favorable fermentation characteristics in the large bowel, and also resulted in a change in bacterial populations. |
| Databáze: | OpenAIRE |
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