Has the prognosis of adult patients with acute myeloid leukemia improved over years? A single institution experience of 784 consecutive patients over a 16-year period
| Autor: | A Beauchamp-Nicoud, Blanc Cm, Jean-Pierre Marie, Bernard Rio, Alain Delmer, Marion Baudard, Zittoun R |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Cancer Research Pediatrics medicine.medical_specialty Antineoplastic Agents Disease-Free Survival hemic and lymphatic diseases medicine Humans Single institution Adult patients business.industry Remission Induction Myeloid leukemia Hematology Middle Aged Prognosis Survival Rate Oncology Leukemia Myeloid Acute Disease Multivariate Analysis Female business Follow-Up Studies |
| Zdroj: | Leukemia. 13:1481-1490 |
| ISSN: | 1476-5551 0887-6924 |
| DOI: | 10.1038/sj.leu.2401544 |
| Popis: | We reviewed the reports of 784 consecutive patients admitted to our department for newly diagnosed acute myeloid leukemia (AML) over a 16-year period. Median, 5-year and 10-year overall survivals were 9. 5 months, 17.3% and 11.7% respectively. Induction treatment (698 patients) resulted in 50% complete remissions (CR) (from 26.5% in secondary AML to 81.2% in patients60 years with de novo AML). Period of diagnosis (1980-84/85-89/90-95) demonstrated a major significance for CR achievement and OS in multivariate analysis. In patients/=60 years (372), CR rate increased (25% to 36.8%, P = 0. 03), and 5-year OS (3.7% to 10.6%, P = 0.022) improved, probably due to an increase in the proportion of patients administered conventional combined chemotherapy (54.5% to 83.8%, P0.0001). In younger patients CR rate continuously increased (61.5% to 74.8%, P = 0.028) with an associated improvement of 5-year OS (19.2% to 35.4%). No significant change in DFS and CR durations was observed. This large single center study on a large cohort of unselected AML patients reflects the improvement achieved in the management of AML patients, likely due to improvement of supportive care practices, administration of conventional induction to more elderly patients, and intensification of induction and post-remission treatments in patients60 years. |
| Databáze: | OpenAIRE |
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