Ultrafiltration within downstream processing: some process design considerations
| Autor: | Gilbert Marcel Rios, Estelle Morin, Marie-Pierre Belleville, E. Darnon |
|---|---|
| Přispěvatelé: | Institut Européen des membranes (IEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM) |
| Rok vydání: | 2003 |
| Předmět: |
Scale-up
General Chemical Engineering Extrapolation Ultrafiltration Energy Engineering and Power Technology Process design 02 engineering and technology Industrial and Manufacturing Engineering Separation [CHIM.GENI]Chemical Sciences/Chemical engineering 020401 chemical engineering [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering 0204 chemical engineering Process engineering Chromatography Downstream processing Computer simulation business.industry Chemistry Process Chemistry and Technology Mass balance General Chemistry 021001 nanoscience & nanotechnology SCALE-UP 0210 nano-technology business Constant (mathematics) Simulation |
| Zdroj: | Chemical Engineering and Processing: Process Intensification Chemical Engineering and Processing: Process Intensification, Elsevier, 2003, 42 (4), pp.299-309. ⟨10.1016/S0255-2701(02)00053-3⟩ |
| ISSN: | 0255-2701 |
| DOI: | 10.1016/s0255-2701(02)00053-3 |
| Popis: | International audience; The use of ultrafiltration (UF) in downstream processing becomes increasingly important. Downstream processing involves complex biological mixture which can not be well-known with simple analytical techniques. That leads to very poor theoretical data on the UF of such solutions. As a consequence, the integration of this operation in downstream processing is somewhere limited and empirical, requiring a lot of experiments. This paper proposes a new method to overcome this difficulty and to transpose data obtained in a laboratory setup to a larger pilot unit. The approach is based on non steady state mass balance equations. On the assumption of constant transmission rates, these equations can be analytically solved. When these assumptions are not accurate, a numerical resolution is proposed. In this study, the simulated results are faced with experimental data obtained with a synthetic bio-solution constituted from a protein hydrolysate (yeast extract) and b-lactoglobulin, filtered on an inorganic Carbosep membrane (cutoff 15 kDa). The contribution of this method to simulate and scale-up UF units is discussed. # |
| Databáze: | OpenAIRE |
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