Comparative Study on Iron Content Detection by Energy Spectral CT and MRI in MDS Patients
| Autor: | Zhao-Wei Li, Shuang Han, Lu-Xi Song, Yao Zhang, Jun-Gong Zhao, Chunkang Chang, Jing Li, Youshan Zhao, Cha Guo, Chao Xiao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cancer Research Liver Iron Concentration Myocardial iron DECT Gastroenterology lcsh:RC254-282 030218 nuclear medicine & medical imaging ASF 03 medical and health sciences 0302 clinical medicine Internal medicine medicine MDS In patient iron overload Serum ferritin Original Research Rbc transfusion Receiver operating characteristic medicine.diagnostic_test Chemistry business.industry Significant difference Magnetic resonance imaging lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Oncology Iron content Nuclear medicine business 030215 immunology MRI |
| Zdroj: | Frontiers in Oncology, Vol 11 (2021) Frontiers in Oncology |
| Popis: | Objective: The purpose of this study was to identify the difference between dual energy spectral computed tomography (DECT) and magnetic resonance imaging (MRI) used to detect liver/cardiac iron content in Myelodysplastic syndrome (MDS) patients with differently adjusted serum ferritin (ASF) levels.Method: Liver and cardiac iron content were detected by DECT and MRI. Patients were divided into different subgroups according to the level of ASF. The receiver operating characteristic curve (ROC) analysis was applied in each subgroup. The correlation between iron content detected by DECT/MRI and ASF was analyzed in each subgroup.Result: ROC curves showed that liver virtual iron content (LVIC) Az was significantly less than liver iron concentration (LIC) Az in the subgroup with ASF < 1,000 ng/ml. There was no significant difference between LVIC Az and LIC Az in the subgroup with 1,000 ≤ ASF < 2,500 ng/ml and 2,500 ≤ ASF < 5,000 ng/ml. LVIC Az was significantly higher than LIC Az in the subgroup with ASF 5,000 mg/L in LIC, LIC became correlated with ASF. There was no significant difference between the subgroup with 2,500 ≤ ASF < 5,000 ng/ml and 5,000 ng/ml ≤ ASF in LIC expression. Furthermore, both LIC and liver VIC had significant correlations with ASF in patients with ASF < 2,500 ng/ml, while LVIC was still correlated with ASF, LIC was not correlated with ASF in patients with 2,500 ng/ml ≤ ASF. Moreover, neither cardiac VIC nor myocardial iron content (MIC) were correlated with ASF in these subgroups.Conclusion: MRI and DECT were complementary to each other in liver iron detection. In MDS patients with high iron content, such as ASF ≥ 5,000 ng/ml, DECT was more reliable than the MRI in the assessment of iron content. But in patients with low iron content, such as ASF < 1,000 ng/ml, MRI is more reliable than DECT. Therefore, for the sake of more accurately evaluating the iron content, the appropriate detection method can be selected according to ASF. |
| Databáze: | OpenAIRE |
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