An IGG M-component reacting with both anti-.KAPPA. and anti-.LAMBDA. light chains in multiple myeloma
| Autor: | SEIJU ONODERA, RYUTARO INABA, ISAO SATO, KAZUYASU ENDO, TAKASHIRO SUZUKI, OSAMU KITAHARA, KATSUKO TAKAIIASHI, SHIGEO SUZUKI, YUKIO IMAMURA |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Myeloma protein
Immunoelectrophoresis Immunoglobulin lambda-Chains Immunoglobulin light chain Immunoglobulin kappa-Chains General Biochemistry Genetics and Molecular Biology Immunoglobulin G medicine Humans Multiple myeloma Aged biology medicine.diagnostic_test Chemistry General Medicine medicine.disease Molecular biology Bence Jones protein Myeloma Proteins biology.protein Female Immunoglobulin Light Chains Multiple Myeloma Bence Jones Protein |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 120:269-275 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.120.269 |
| Popis: | A patient with multiple myeloma who has an IgG-IM-component in serum reacting with both kappa and lambda light chains in immunoelectrophoresis is presented. The possibility of "hybrid molecule (H2LkappaLlambda)" is strongly suspected. The absorption studies of the patient's serum employing anti-kappa and anti-lambda light chains, however, support the view that this apparently single M-component consists of two M-components, IgG 1-kappa and IgG 1-lambda. The reason why these two M-components possessed the identical electrophoretic mobility is unclear. The possibility is high that these two M-components are produced in the same cell. |
| Databáze: | OpenAIRE |
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