Ethanol-Induced Changes in Cardiac Lipid Metabolism
| Autor: | P. W. Colley, Romano C. Pirola, John B. Somer, Jeremy S. Wilson |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Calorie Medicine (miscellaneous) Stimulation Toxicology chemistry.chemical_compound Internal medicine medicine Animals Diglyceride Phospholipids Triglycerides Ethanol Triglyceride Cardiomyopathy Alcoholic Myocardium Rats Inbred Strains Lipid metabolism Metabolism Lipid Metabolism Rats Psychiatry and Mental health Cholesterol Endocrinology chemistry Lipogenesis Female Cholesterol Esters |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 5:536-539 |
| ISSN: | 1530-0277 0145-6008 |
| Popis: | The influence of ethanol on cardiac lipid metabolism has been investigated in the rat. Acute in vitro ethanol significantly stimulated the incorporation of 14C-1-acetate but not 14C-U-glucose into cardiac lipid in rats fed a diet free of ethanol for 3 weeks. Stimulation of incorporation was not uniform but was confined to the diglyceride and triglyceride fractions. This response of cardiac tissue lipid metabolism to acute ethanol was not observed in rats pair fed an isocaloric diet containing 36% of calories as ethanol. Chronic ethanol feeding significantly increased cardiac triglyceride content when compared with pair-fed controls. It also stimulated oxidation of labeled palmitate, but did not affect in vitro lipogenesis. |
| Databáze: | OpenAIRE |
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