Men and women have an equal oropharyngeal and anorectal Chlamydia trachomatis bacterial load
| Autor: | Petra F. G. Wolffs, Christian J. P. A. Hoebe, Geneviève A F S van Liere, Nicole H. T. M. Dukers-Muijrers, Juliën N. A. P. Wijers, Jeanne A. M. C. Dirks |
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| Přispěvatelé: | RS: CAPHRI - R4 - Health Inequities and Societal Participation, Promovendi PHPC, Med Microbiol, Infect Dis & Infect Prev, MUMC+: DA MMI AIOS (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, MUMC+: DA MMI Moleculaire dia (9), MUMC+: DA MMI Management (9), Sociale Geneeskunde |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty 030106 microbiology Oropharynx Chlamydia trachomatis HIV Infections Partial immunity Urine DETERMINANTS medicine.disease_cause CULTURE 03 medical and health sciences 0302 clinical medicine Internal medicine INFECTION medicine Humans Immunology and Allergy Clinical significance oropharyngeal 030212 general & internal medicine Chlamydia REAL-TIME PCR urogenital Multivariable linear regression Genitourinary system business.industry CLINICAL-FEATURES bacterial load Rectum Chlamydia Infections medicine.disease Infectious Diseases anorectal extragenital Vagina Vaginal swabs Female NEISSERIA-GONORRHOEAE business |
| Zdroj: | Journal of Infectious Diseases, 223(9), 1582-1589. Oxford University Press |
| ISSN: | 0022-1899 |
| DOI: | 10.1093/infdis/jiz668 |
| Popis: | Background The Chlamydia trachomatis bacterial load could have impact on transmission and sequelae. This is the first study providing comparison of C. trachomatis load at 3 anatomic sites estimated by cycle quantification (Cq) values. Methods Data from 7900 C. trachomatis-positive samples were included (2012–2018). Cq value was used as an inversely proportional measure for C. trachomatis load. Multivariable linear regression analyses assessed differences in mean Cq values. Results Vaginal swabs had the lowest Cq values (31.0) followed by urine (32.5), anorectal swabs (34.0), and oropharyngeal swabs (36.8) (P < .001). Men and women had similar oropharyngeal (36.4 vs 37.3; P = .13) and anorectal (34.2 vs 33.9; P = .19) Cq values. Men (32.2) and women (30.7) aged Conclusions Men and women have a similar C. trachomatis load at extragenital locations arguing for similar transmission potential and clinical relevance. Older patients and HIV-coinfected patients had lower C. trachomatis load, suggesting exposure to previous C. trachomatis infections potentially leading to partial immunity reducing load. |
| Databáze: | OpenAIRE |
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