General approach for the chromatographic determination of 2-hydroxypyridine-1-oxide (HOPO) in pharmaceutically relevant materials utilizing a high pH ion-pairing strategy
| Autor: | Scott M. Thomas, Bing Mao, Justin R. Denton |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Chromatography
Molecular Structure Pyridines Ion pairing Clinical Biochemistry Oxide Pharmaceutical Science Stereoisomerism Method development Analytical Chemistry Cyclic N-Oxides chemistry.chemical_compound chemistry Pharmaceutical Preparations Limit of Detection Drug Discovery Trace analysis Drug Contamination Amide bonds Spectroscopy Chromatography High Pressure Liquid |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 115 |
| ISSN: | 1873-264X |
| Popis: | 2-Hydroxypyridine-1-oxide (HOPO) is utilized in the pharmaceutical sector to facilitate the formation of amide bonds. This present work describes the development of a HPLC high pH ion-pairing method for the trace analysis of HOPO in pharmaceutically relevant materials. Several method development aspects are discussed and the application of this method to several late-stage programs is presented. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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