Dietary magnesium intake alters age-related changes in rat adipose tissue cellularity
| Autor: | Markus Adrian, Pascal Laurant, Sylvie Devaux, Alain Berthelot, Annie Quignard-Boulangé |
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| Přispěvatelé: | Pathologies et épithéliums : prévention, innovation, traitements, évaluation (EA 4267) (PEPITE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris-Saclay, INSERM, Universite Paris Diderot, Association Francois Aupetit, labex inflamex, Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Franche-Comté (UFC), AgroParisTech-Institut National de la Recherche Agronomique (INRA) |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Aging adipocytes [SDV]Life Sciences [q-bio] Clinical Biochemistry Adipose tissue Biochemistry leptin Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound cellularity Adipocyte Internal medicine medicine Animals Magnesium Young adult Molecular Biology Cell Proliferation Cell Size 2. Zero hunger 030109 nutrition & dietetics business.industry Cell growth Leptin blood pressure Lipid metabolism medicine.disease Lipid Metabolism Obesity 3. Good health Rats Endocrinology Blood pressure chemistry Adipose Tissue Dietary Supplements business |
| Zdroj: | Magnesium Research Magnesium Research, John Libbey Eurotext, 2016, 29 (4), pp.175-182. ⟨10.1093/ecco-jcc/jjw095⟩ Magnesium Research, John Libbey Eurotext, 2016, 29 (4), pp.175-182. ⟨10.1684/mrh.2016.0406⟩ |
| ISSN: | 1952-4021 0953-1424 |
| DOI: | 10.1093/ecco-jcc/jjw095⟩ |
| Popis: | Obesity and related metabolic diseases are associated with increased risk of cardiovascular disease. We have previously shown the beneficial effects of dietary magnesium (Mg) supplementation on cardiovascular disease in rats. Therefore, we aimed to examine the effect of an Mg-deficient or supplemented diet on adipose tissue cellularity changes during aging, and on blood pressure (BP), in rats. Male rats received for one (young adult) or 22 months (old), an Mg-deficient (Def) (150 mg/kg), standard (Std) (800 mg/kg) or Mg-supplemented (Sup) (3200 mg/kg) diet. Adipose tissue development and cellularity, BP and leptinemia were evaluated. In rats fed a standard diet, the large increase in adipose tissue weight observed during aging was related to an increase in both size and number of adipocytes. In young adult rats, although adiposity was unchanged, Mg supplementation resulted in a shift of the frequency distribution of adipocytes toward greater sizes, adipose cell weight increasing by 62%. Mg deficiency did not modify adipocyte size, but increased their number (30% more than for the standard or Sup-diet). In old rats, the Def-diet led to relative adipocyte hypotrophy, which was counterbalanced by an increase in the number of adipocyte. Conversely, adipocyte size and number were similar in the Sup-diet and standard diet-fed rats. BP was modified in old rats according to dietary Mg, whereas it remained unchanged young adult rats regardless of the diet received. This study suggests that Mg intake may affect age-related changes in rat adipose tissue lipid storage capacity. |
| Databáze: | OpenAIRE |
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