Chemical Constituents of the Methanolic Extract of Leaves of Leiothrix spiralis Ruhland and Their Antimicrobial Activity
| Autor: | Lourdes Campaner dos Santos, Taís Maria Bauab, Felipe Hilário, Marcelo Gonzaga de Freitas Araújo, Wagner Vilegas, L. G. Nogueira |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Eriocaulaceae
Leiothrix spiralis phenolic compounds antimicrobial activity Pharmaceutical Science Microbial Sensitivity Tests Candida parapsilosis medicine.disease_cause Enterococcus faecalis Article Analytical Chemistry Microbiology lcsh:QD241-441 Minimum inhibitory concentration lcsh:Organic chemistry Anti-Infective Agents Drug Discovery medicine Physical and Theoretical Chemistry Candida albicans Escherichia coli biology Bacteria Plant Extracts Methanol Organic Chemistry Fungi biology.organism_classification Antimicrobial Plant Leaves Chemistry (miscellaneous) Staphylococcus aureus Molecular Medicine |
| Zdroj: | Molecules Molecules; Volume 16; Issue 12; Pages: 10479-10490 Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Molecules, Vol 16, Iss 12, Pp 10479-10490 (2011) |
| ISSN: | 1420-3049 |
| Popis: | Made available in DSpace on 2013-08-28T14:07:40Z (GMT). No. of bitstreams: 1 WOS000298411200051.pdf: 226055 bytes, checksum: 93b04514495b3ddc254d473afd2f177e (MD5) Made available in DSpace on 2013-09-30T19:10:43Z (GMT). No. of bitstreams: 2 WOS000298411200051.pdf: 226055 bytes, checksum: 93b04514495b3ddc254d473afd2f177e (MD5) WOS000298411200051.pdf.txt: 36780 bytes, checksum: e31ab34a113edb9197d9c036c531e4a8 (MD5) Previous issue date: 2011-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:21:18Z No. of bitstreams: 2 WOS000298411200051.pdf: 226055 bytes, checksum: 93b04514495b3ddc254d473afd2f177e (MD5) WOS000298411200051.pdf.txt: 36780 bytes, checksum: e31ab34a113edb9197d9c036c531e4a8 (MD5) Made available in DSpace on 2014-05-20T14:21:18Z (GMT). No. of bitstreams: 2 WOS000298411200051.pdf: 226055 bytes, checksum: 93b04514495b3ddc254d473afd2f177e (MD5) WOS000298411200051.pdf.txt: 36780 bytes, checksum: e31ab34a113edb9197d9c036c531e4a8 (MD5) Previous issue date: 2011-12-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação para o Desenvolvimento da UNESP (FUNDUNESP) Chemical fractionation of the methanolic extract of leaves of Leiothrix spiralis Ruhland afforded the flavonoids luteolin- 6- C-beta-D-glucopyranoside (1), 7-methoxyluteolin-6-C-beta-D-glucopyranoside (2), 7-methoxyluteolin-8-C-beta-D-glucopyranoside (3), 4'-methoxyluteolin-6-C-beta-D-glucopyranoside (4), and 6- hydroxy-7-methoxyluteolin (5), and the xanthones 8-carboxymethyl-1,5,6-trihydroxy-3-methoxyxanthone (6), 8-carboxymethyl-1,3,5,6- tetrahydroxyxanthone (7). Methanolic extract, fractions, and isolated compounds of the leaves of L. spiralis were assayed against Gram-positive (Staphylococcus aureus, Bacillus subtilis and Enterococcus faecalis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella setubal and Helicobacter pylori) and fungi (the yeasts Candida albicans, C. tropicalis, C. krusei and C. parapsilosis). We observed the best minimum inhibitory concentration values for the methanolic extract against Candida parapsilosis, for the fraction 5 + 6 against Gram-negative bacteria E. coli and P. aeruginosa, and compound 7 against all tested Candida strains. The methanolic extract contents suggest that this species may be a promising source of compounds to produce natural phytomedicines. São Paulo State Univ UNESP, Fac Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil São Paulo State Univ UNESP, Dept Organ Chem, Inst Chem, BR-14800900 Araraquara, SP, Brazil São Paulo State Univ UNESP, Fac Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil São Paulo State Univ UNESP, Dept Organ Chem, Inst Chem, BR-14800900 Araraquara, SP, Brazil |
| Databáze: | OpenAIRE |
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