TRANSPATH(R): an information resource for storing and visualizing signaling pathways and their pathological aberrations
| Autor: | Deborah Kronenberg, Claudia Choi, Holger Michael, Olga V. Kel-Margoulis, Alexander E. Kel, Nico Voss, Mathias Krull, Anatolij P Potapov, Knut Schwarzer, Ingmar Reuter, Susanne Pistor, Edgar Wingender |
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| Přispěvatelé: | Deleage, Gilbert |
| Rok vydání: | 2006 |
| Předmět: |
Genetics
Internet Genotype Genetic Diseases Inborn Construct (python library) Computational biology Biology Article User-Computer Interface Phenotype Information resource Databases Genetic Mutation Computer Graphics [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology Humans Signal transduction Protein Processing Post-Translational Signal Transduction |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | TRANSPATH[superscript ®] is a database about signal transduction events. It provides information about signaling molecules, their reactions and the pathways these reactions constitute. The representation of signaling molecules is organized in a number of orthogonal hierarchies reflecting the classification of the molecules, their species-specific or generic features, and their post-translational modifications. Reactions are similarly hierarchically organized in a three-layer architecture, differentiating between reactions that are evidenced by individual publications, generalizations of these reactions to construct species-independent 'reference pathways' and the 'semantic projections' of these pathways. A number of search and browse options allow easy access to the database contents, which can be visualized with the tool PathwayBuilder[superscript TM]. The module PathoSign adds data about pathologically relevant mutations in signaling components, including their genotypes and phenotypes. TRANSPATH[superscript ®] and PathoSign can be used as encyclopaedia, in the educational process, for vizualization and modeling of signal transduction networks and for the analysis of gene expression data. TRANSPATH[superscript ®] Public 6.0 is freely accessible for users from non-profit organizations under http://www.gene-regulation.com/pub/databases.html. |
| Databáze: | OpenAIRE |
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