TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-associated dementia

Autor: Yunlong Huang, Hui Peng, You Zhou, Jialin C. Zheng, Yuri Persidsky, David Erichsen, Lisa A. Ryan, Howard E. Gendelman
Rok vydání: 2004
Předmět:
Adult
Lipopolysaccharides
Male
AIDS Dementia Complex
Immunology
HIV Core Protein p24
Apoptosis
Cell Count
Enzyme-Linked Immunosorbent Assay
Monocytes
Receptors
Tumor Necrosis Factor
TNF-Related Apoptosis-Inducing Ligand
In Situ Nick-End Labeling
medicine
Humans
Immunology and Allergy
Macrophage
Cytotoxic T cell
Receptor
Cells
Cultured
Caspase
Neurons
Acquired Immunodeficiency Syndrome
Membrane Glycoproteins
biology
Tumor Necrosis Factor-alpha
Neurotoxicity
Antibodies
Monoclonal
Mononuclear phagocyte system
Human brain
Middle Aged
Embryo
Mammalian
Flow Cytometry
medicine.disease
Immunohistochemistry
Receptors
TNF-Related Apoptosis-Inducing Ligand
medicine.anatomical_structure
Neurology
Caspases
Cancer research
biology.protein
Female
Neurology (clinical)
Apoptosis Regulatory Proteins
Microtubule-Associated Proteins
Zidovudine
Zdroj: Journal of Neuroimmunology. 148:127-139
ISSN: 0165-5728
DOI: 10.1016/j.jneuroim.2003.11.019
Popis: TNF-related apoptosis-inducing ligand (TRAIL) is a type II integral membrane protein that interacts with multiple receptors and cell types including neurons. In this report, TRAIL protein levels were increased in human monocyte-derived macrophages (MDM) after HIV-1 infection and immune activation. In HIV-1 encephalitic (HIVE) human brain tissue, TRAIL-expressing macrophages were found in association with active caspase-3 positive neurons. Cytotoxic TRAIL receptors 1 and 2 were expressed on neurons in primary human fetal cultures and HIV-1 encephalitic brain tissue. Furthermore, TRAIL induced a dose-dependent effect on neuronal apoptosis. These results support a role for TRAIL in mononuclear phagocyte (MP)-mediated neurotoxicity in HIV-1-associated dementia (HAD).
Databáze: OpenAIRE
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