Antioxidative and haematoprotective activity of coenzyme Q10 and vitamin E against cadmium-induced oxidative stress in Wistar rats
| Autor: | Branka I. Ognjanović, Miloš M. Matić, Milica G. Paunović, Zorica S. Saičić |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Erythrocytes Ubiquinone Health Toxicology and Mutagenesis medicine.medical_treatment Glutathione reductase Pharmacology Toxicology medicine.disease_cause Antioxidants Lipid peroxidation Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Vitamin E Rats Wistar Coenzyme Q10 chemistry.chemical_classification biology Glutathione peroxidase Public Health Environmental and Occupational Health Glutathione Rats 3. Good health Oxidative Stress 030104 developmental biology chemistry Oxidative stress biology.protein Antioxidative defence 030217 neurology & neurosurgery Cadmium |
| Zdroj: | Toxicology and industrial health |
| ISSN: | 1477-0393 0748-2337 |
| Popis: | Cadmium (Cd) is a major environmental pollutant, which exerts adverse effects mainly by inducing oxidative stress. Coenzyme Q10(CoQ10) and vitamin E (VE), naturally occurring antioxidants, improve health condition by inactivating free radicals and enhancing antioxidative defence. The aim of our study was to investigate the protective role of CoQ10and/or VE pretreatment against Cd-induced haematotoxicity. Wistar albino rats were intramuscularly injected with CoQ10(20 mg/kg b.w.) and/or VE (20 IU/kg b.w.) or with saline (control group). After 24 h, Cd was injected intraperitoneally (0.4 mg/kg b.w.) and 1 day after, animals were sacrificed. Acute Cd intoxication caused significant changes in haematological and biochemical parameters and altered the glutathione cycle, leading to the formation of lipid peroxidation, while the concentrations and activities of antioxidants (vitamins C and E, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) were decreased. CoQ10and/or VE significantly maintained these values to near-normal levels, afforded additional protection by reducing lipid peroxidation and improved the levels of antioxidants in the blood. Plasma CoQ10and VE levels negatively correlated with oxidative damage parameters while positively correlated with antioxidative defence parameters. Regarding their effects, CoQ10and VE were in synergistic interaction. The present study suggested that CoQ10and VE combination may be beneficial in protecting from Cd-induced haematotoxicity and may be used as a preventive against acute Cd intoxication of exposed people. |
| Databáze: | OpenAIRE |
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