Vasculitis in patients with systemic sclerosis and severe digital ischaemia requiring amputation
| Autor: | Anthony J. Freemont, M Haeney, P K Oogarah, R. Marcuson, Malcolm I. V. Jayson, Ariane L. Herrick |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Vasculitis Systemic disease medicine.medical_specialty medicine.medical_treatment Immunology General Biochemistry Genetics and Molecular Biology Scleroderma Amputation Surgical Fingers Rheumatology Ischemia Immunology and Allergy Medicine Humans cardiovascular diseases skin and connective tissue diseases Retrospective Studies Scleroderma Systemic integumentary system business.industry Vascular disease musculoskeletal neural and ocular physiology Retrospective cohort study Arteries Middle Aged medicine.disease Connective tissue disease Surgery Amputation Antibodies Anticardiolipin Female business Complication Research Article |
| Zdroj: | Annals of the rheumatic diseases. 53(5) |
| ISSN: | 0003-4967 |
| Popis: | OBJECTIVES--To document the incidence of histological vasculitis in amputation specimens from patients with severe digital ischaemia secondary to systemic sclerosis (SSc), and to look for an association between anticardiolipin (aCL) antibodies and severe digital ischaemia in SSc. METHODS--This was a retrospective review of patients with SSc who underwent amputation for digital ischaemia over a three year period. RESULTS--Five of nine patients had histological vasculitis, four of whom had aCL antibodies, although these were not present in high titre. CONCLUSION--Vasculitis does occur in SSc, at least in that subgroup with severe peripheral ischaemia. These findings could have implications for treatment of this subgroup of patients with SSc. |
| Databáze: | OpenAIRE |
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