Validation of Calprotectin As a Novel Biomarker For The Diagnosis of Pleural Effusion: a Multicentre Trial

Autor:	Laura García-Nimo, Francisco Javier Rodríguez-Berrocal, Maribel Botana-Rial, Alberto Fernández-Villar, Lucía Ferreiro-Fernández, Luis Valdés-Cuadrado, María Páez de la Cadena, José Abal-Arca, María Amalia Andrade-Olivié, Pedro Casado-Rey, María Esther San-José, Lorena Vázquez-Iglesias
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Male medicine.medical_specialty Multivariate analysis Pleural effusion lcsh:Medicine Sensitivity and Specificity Gastroenterology Article Diagnosis Differential Tumour biomarkers 03 medical and health sciences 0302 clinical medicine 32 Ciencias Médicas Internal medicine Biomarkers Tumor medicine Humans Diagnostic biomarker Malignant pleural effusion lcsh:Science Aged Aged 80 and over 2302.21 Biología Molecular Multidisciplinary business.industry 2409 Genética lcsh:R Area under the curve Reproducibility of Results Diagnostic markers Middle Aged medicine.disease Pleural Effusion Malignant Pleural Effusion ROC Curve 030228 respiratory system Spain Area Under Curve 030220 oncology & carcinogenesis Etiology Pleura Biomarker (medicine) Female lcsh:Q Calprotectin business Leukocyte L1 Antigen Complex 3207.13 Oncología
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) Investigo. Repositorio Institucional de la Universidade de Vigo Universidade de Vigo (UVigo) Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-020-62388-y
Popis:	Discriminating between malignant pleural effusion (MPE) and benign pleural effusion (BPE) remains difficult. Thus, novel and efficient biomarkers are required for the diagnosis of pleural effusion (PE). The aim of this study was to validate calprotectin as a diagnostic biomarker of PE in clinical settings. A total of 425 patients were recruited, and the pleural fluid samples collected had BPE in 223 cases (53.7%) or MPE in 137 patients (33%). The samples were all analysed following the same previously validated clinical laboratory protocols and methodology. Calprotectin levels ranged from 772.48 to 3,163.8 ng/mL (median: 1,939 ng/mL) in MPE, and 3,216–24,000 ng/mL in BPE (median: 9,209 ng/mL; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abea8353c32244a4e4213cd08262daf http://link.springer.com/article/10.1038/s41598-020-62388-y Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.