Tissue distribution of human gamma delta T cells: no evidence for general epithelial tropism
| Autor: | T. M. Vroom, Jannie Borst, G Scholte, Ferry Ossendorp |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pathology
medicine.medical_specialty Hematopoietic System T cell Respiratory System Population Urogenital System Biology Epithelium Pathology and Forensic Medicine Lymphatic System Immune system Antigen T-Lymphocyte Subsets medicine Humans education Tropism Skin education.field_of_study T-cell receptor Receptors Antigen T-Cell gamma-delta General Medicine T lymphocyte Molecular biology medicine.anatomical_structure Lymphatic system Digestive System Research Article |
| Zdroj: | Journal of Clinical Pathology. 44:1012-1017 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.44.12.1012 |
| Popis: | In man and mice only a small proportion of T cells in the peripheral lymphoid compartment express the gamma delta T cell receptor (TCR). In mice, however, gamma delta T cells comprise the predominant population at particular epithelial sites--in epidermis and epithelia of intestine, reproductive organs, and tongue. The distribution of gamma delta T cells in normal human tissues was investigated, paying particular attention to epithelial layers. In all lymphatic organs and in epithelia of a wide variety of non-lymphatic organs, including the respiratory tract, male and female reproductive organs and tongue, gamma delta T cells constituted less than 5% of total T cells, with the remainder expressing TCR alpha beta. The only exception was the intestine, where gamma delta T cells were preferentially situated in the columnar epithelium of the crypts, rather than in the lamina propria. It is concluded, therefore, that human gamma delta T cells do not display a general epithelial tropism and are, in terms of relative numbers, no more able than alpha beta T cells to carry out continuous surveillance of the immune system against infection or transformation in epithelia. gamma delta T cells may, however, have a specialised function in the epithelium of the intestinal tract. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|