Non-linear association between diabetes mellitus and pulmonary function: a population-based study
Autor: | Jian-Bo Zhou, Lin Ping Shu, Yao Hua Cai, Rui-Heng Zhang, Rafael Simó, Albert Lecube |
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Rok vydání: | 2020 |
Předmět: |
Adult
Blood Glucose Lung Diseases Male medicine.medical_specialty Vital capacity Pulmonary function National Health and Nutrition Examination Survey Vital Capacity Population 030209 endocrinology & metabolism Risk Assessment Pulmonary function testing 03 medical and health sciences Diabetes mellitus 0302 clinical medicine Insulin resistance Risk Factors Forced Expiratory Volume Internal medicine Humans NHANES Medicine 030212 general & internal medicine education Lung Glycemic Glycated Hemoglobin lcsh:RC705-779 education.field_of_study Mediation Analysis business.industry Research lcsh:Diseases of the respiratory system Middle Aged Nutrition Surveys medicine.disease Obesity United States C-Reactive Protein Cross-Sectional Studies Nonlinear Dynamics Female Insulin Resistance business Biomarkers |
Zdroj: | Repositorio Abierto de la UdL Universitad de Lleida Respiratory Research, Vol 21, Iss 1, Pp 1-9 (2020) Respiratory Research |
ISSN: | 1465-993X |
Popis: | Background: There is increasing evidence that the lung is a target organ of diabetes. This study aimed to examine in detail the association between diabetes mellitus and pulmonary function using a national cohort. We also aimed to explore the non-linear association between pulmonary function and blood glucose, insulin resistance, and C-reactive protein (CRP). Methods: A total of 30,442 participants from the National Health and Nutrition Examination Survey from the period between 2007 and 2012 were included. The cross-sectional association between diabetes mellitus and pulmonary function was assessed using multiple linear regression. Where there was evidence of non-linearity, we applied a restricted cubic spline with three knots to explore the non-linear association. Partial mediation analysis was performed to evaluate the underlying mechanism. All analyses were weighted to represent the US population and to account for the intricate survey design. Results: A total of 8584 people were included in the fnal study population. We found that diabetes was signifcantly associated with reduced forced expiratory volume in one second (FEV1) and forced vital capacity. We further found L-shaped associations between hemoglobin A1c (HbA1c) and pulmonary function. There was a negative association between HbA1c and FEV1 in diabetes participants with good glucose control (HbA1c |
Databáze: | OpenAIRE |
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