Non-linear association between diabetes mellitus and pulmonary function: a population-based study

Autor: Jian-Bo Zhou, Lin Ping Shu, Yao Hua Cai, Rui-Heng Zhang, Rafael Simó, Albert Lecube
Rok vydání: 2020
Předmět:
Adult
Blood Glucose
Lung Diseases
Male
medicine.medical_specialty
Vital capacity
Pulmonary function
National Health and Nutrition Examination Survey
Vital Capacity
Population
030209 endocrinology & metabolism
Risk Assessment
Pulmonary function testing
03 medical and health sciences
Diabetes mellitus
0302 clinical medicine
Insulin resistance
Risk Factors
Forced Expiratory Volume
Internal medicine
Humans
NHANES
Medicine
030212 general & internal medicine
education
Lung
Glycemic
Glycated Hemoglobin
lcsh:RC705-779
education.field_of_study
Mediation Analysis
business.industry
Research
lcsh:Diseases of the respiratory system
Middle Aged
Nutrition Surveys
medicine.disease
Obesity
United States
C-Reactive Protein
Cross-Sectional Studies
Nonlinear Dynamics
Female
Insulin Resistance
business
Biomarkers
Zdroj: Repositorio Abierto de la UdL
Universitad de Lleida
Respiratory Research, Vol 21, Iss 1, Pp 1-9 (2020)
Respiratory Research
ISSN: 1465-993X
Popis: Background: There is increasing evidence that the lung is a target organ of diabetes. This study aimed to examine in detail the association between diabetes mellitus and pulmonary function using a national cohort. We also aimed to explore the non-linear association between pulmonary function and blood glucose, insulin resistance, and C-reactive protein (CRP). Methods: A total of 30,442 participants from the National Health and Nutrition Examination Survey from the period between 2007 and 2012 were included. The cross-sectional association between diabetes mellitus and pulmonary function was assessed using multiple linear regression. Where there was evidence of non-linearity, we applied a restricted cubic spline with three knots to explore the non-linear association. Partial mediation analysis was performed to evaluate the underlying mechanism. All analyses were weighted to represent the US population and to account for the intricate survey design. Results: A total of 8584 people were included in the fnal study population. We found that diabetes was signifcantly associated with reduced forced expiratory volume in one second (FEV1) and forced vital capacity. We further found L-shaped associations between hemoglobin A1c (HbA1c) and pulmonary function. There was a negative association between HbA1c and FEV1 in diabetes participants with good glucose control (HbA1c
Databáze: OpenAIRE
Externí odkaz: