Hepatoprotective and Renoprotective Properties of Lovastatin-Loaded Ginger and Garlic Oil Nanoemulsomes: Insights into Serum Biological Parameters
| Autor: | Ikram Ullah Khan, Muhammad Asif, Tanveer Hussain, Umar Farooq Gohar, Ikrima Khalid, Syed Ali Faran, Sajid Asghar, Syed Haroon Khalid |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Medicine (General) Garlic Oil Administration Oral lovastatin hepatoprotective Pharmacology Kidney chemistry.chemical_compound 0302 clinical medicine Hyperlipidemia anti-hyperlipidemia Blood urea nitrogen Hypolipidemic Agents 0303 health sciences biology garlic oil Liver Diseases nanoemulsomes General Medicine ginger oil Liver 030220 oncology & carcinogenesis Emulsions Kidney Diseases Lovastatin medicine.drug Globulin Serum albumin Hyperlipidemias Ginger Article 03 medical and health sciences R5-920 medicine Animals Plant Oils renoprotective Rats Wistar Garlic 030304 developmental biology Creatinine business.industry medicine.disease Nanostructures Rats chemistry biology.protein Anti-Obesity Agents business Dyslipidemia |
| Zdroj: | Medicina, Vol 55, Iss 9, p 579 (2019) Medicina Volume 55 Issue 9 Medicina; Volume 55; Issue 9; Pages: 579 |
| Popis: | Background and Objectives: Dyslipidemia is gaining much attention among healthcare professionals because of its high association with the malfunctioning of a number of normal physiological and metabolic processes in the body. Obesity is directly interconnected with dyslipidemia and is said to be a denouement of hyperlipidemia and, if left untreated, may lead to intense damage to organs that are directly involved in fat metabolism. The objective of this study was to investigate the synergistic antiobesity and anti-hyperlipidemic activities along with hepato- and renoprotective potential of nanoemulsomes (NES) of lovastatin (LTN)-loaded ginger (GR) and garlic (GL) oils. Materials and Methods: LTN nanoemulsomes co-encapsulated with GR oil and GL oil were prepared by a thin hydration technique. Eight-week-old male Wistar rats weighing 200&ndash 250 g were induced with hyperlipidemia via a high-fat diet (HFD) comprising 40% beef tallow. Body weight, serum biochemical lipid parameters, and those for liver and kidney functions, serum TC, LDL-C, vLDL-C, HDL-C, TG, atherogenic index (AI), ALT, AFT, ALP, &gamma GT, total protein (TP), serum albumin and globulin ratio (A/G), serum creatinine, blood urea nitrogen (BUN) and blood urea, and histopathology of hematoxylin and eosin (H& E) stained liver and kidney sections of all aforementioned groups were examined in the treated animals. Results: Nanoemulsomes of LTN-loaded GR and GL oils provided synergistic effects with LTN, exerted better ameliorative actions in reducing serum TC, LDL-C, vLDL-C, triglycerides, and AI, and improved serum HDL-C levels. Serum ALT, AST, ALP, and &gamma GT levels were in the normal range for nanoemulsome groups. H& E stained liver and kidney sections of these animals confirmed better hepatoprotective and renoprotective effects than LTN alone. Serum biochemical parameters for renal functions also claimed to be in the moderate range for nanoemulsome-treated groups. Conclusion: This study demonstrated that nanoemulsomes of LTN-loaded GR and GL oils synergistically provided better antihyperlipidemic, hepatoprotective, and renoprotective effects as compared to LTN alone. |
| Databáze: | OpenAIRE |
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