Cephamycin inactivation due to enzymatic hydrolysis by beta-lactamase from Bacteroides fragilis
| Autor: | Akira Yotsuji, Matsuhisa Inoue, Shinzaburo Minami, Susumu Mitsuhashi, Saikawa Isamu, H Kakizawa, A Takai, T Yasuda |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Cephalosporin Microbial Sensitivity Tests beta-Lactamases Microbiology Bacteroides fragilis Clavulanic Acids Enzymatic hydrolysis polycyclic compounds medicine Pharmacology (medical) Cefbuperazone Cephamycins Clavulanic Acid Moxalactam Pharmacology biology Hydrolysis Penicillin G biology.organism_classification Cephalosporins Infectious Diseases Biochemistry Beta-lactamase beta-Lactamase Inhibitors Cephamycin Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 28:773-777 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.28.6.773 |
| Popis: | The susceptibility of 53 clinical isolates of Bacteroides fragilis to cephamycins was examined. Judging from the MICs for 50% of the strains tested, moxalactam was the most active, however, judging from the MICs for 90% of the strains tested, cefbuperazone was more effective than moxalactam. A correlation was observed between in vitro activity of benzylpenicillin and cephaloridine and beta-lactamase production. Inactivation due to enzymatic hydrolysis of cephamycins over a short time was not observed; however, inactivation was detected by a double disk diffusion test, and moxalactam was most easily inactivated. We conclude that inactivation due to enzymatic hydrolysis of cephamycins over a long time may play an important role in resistance to some cephamycins in strains of B. fragilis. |
| Databáze: | OpenAIRE |
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