Recent Synthetic Approaches and Biological Evaluations of Amino Hexahydroquinolines and Their Spirocyclic Structures
| Autor: | Doaa M. Abdelmoniem, Amr M. Abdelmoniem, Ismail A. Abdelhamid, Magda F. Mohamed, Said A. S. Ghozlan |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Cancer Research Double bond Bacteria Dose-Response Relationship Drug 010405 organic chemistry Antineoplastic Agents 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Anti-Bacterial Agents Structure-Activity Relationship chemistry Yield (chemistry) Neoplasms Michael reaction Hydroxyquinolines Molecular Medicine Humans Spiro Compounds |
| Zdroj: | Anti-cancer agents in medicinal chemistry. 19(7) |
| ISSN: | 1875-5992 |
| Popis: | In this review, the recent synthetic approaches of amino hexahydroquinolines and their spirocyclic structures were highlighted. The synthetic routes include, two-components, three-components or fourcomponents reactions. The two-component [3+3] atom combination reaction represents the simplest method. It involves Michael addition of the electron rich β-carbon of β-enaminones to the activated double bond of cinnamonitriles followed by cyclization to yield hexahydroquinoline compounds. The bioactivity profiles and SAR studies of these compounds were also reviewed with emphasis to the utility of these substances as antimicrobial, anticancer and antitubercular agents, as well as calcium channel modulators. |
| Databáze: | OpenAIRE |
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