Morphological and Biochemical Characteristics of Prostate Hyperplasia during Sulpiride Treatment
| Autor: | O Y Bredova, V A Mkhitarov, V F Ostrov, I.S. Tsvetkov, A. M. Kosyreva, E A Postovalova, O V Makarova, D N Khochanskiy |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Prostatic Hyperplasia Gene Expression Acinar Cells Injections Intramuscular General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Blood serum Antigen Prostate Internal medicine medicine Animals Humans Testosterone business.industry Epithelial Cells General Medicine Prostate-Specific Antigen Hyperplasia medicine.disease Epithelium Prolactin Rats Disease Models Animal Ki-67 Antigen 030104 developmental biology medicine.anatomical_structure Endocrinology Prostate hyperplasia Dopamine Antagonists Sulpiride business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 168:533-537 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | We studied morphological changes in the prostate ventral lobe, proliferative activity of the epithelium in prostate acini, and the levels of prolactin and prostate-specific antigen in the blood serum of Sprague-Dawley rats after repeated injections of sulpiride in a dose of 40 mg/ kg over 30 and 60 days and in 10 and 30 days after withdrawal. Morphological and morphometrical analysis of hyperplastic changes in the prostate ventral lobe was performed. Ki-67+ proliferating epithelial cells in the acini were counted. The dynamics of serum concentrations of prolactin and prostate-specific antigen was evaluated by ELISA. Morphological and morphometrical analysis and evaluation of the content of Ki-67+ cells demonstrated epithelium hyperplasia in the prostate ventral lobe after sulpiride treatment for 30 or 60 days and in 10 days after withdrawal, but serum level of prostate-specific antigen did not differ from the control. After 60-day sulpiride treatment and in 30 days after withdrawal, pronounced hyperplastic changes of prostate and elevated concentrations of prostate-specific antigen (but not prolactin) were observed. Thus, administration of sulpiride (40 mg/kg) to Sprague-Dawley rats for 60 days allows, by morphological criteria and serum level of prostate-specific antigen, to model stable hyperplastic changes in the prostate corresponding to benign prostatic hyperplasia in humans. |
| Databáze: | OpenAIRE |
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