Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles
| Autor: | Florian Riporto, Vasyl Kilin, John A. Capobianco, Yannick Mugnier, Christophe Mas, Gabriel Campargue, Jean-Pierre Wolf, Alice Vieren, Alfred Vogel, Davide Staedler, Ina Fureraj, Tarek Sabri, John Collins, Sim Sakong, Luigi Bonacina |
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| Přispěvatelé: | Group of Applied Physics - Biophotonics [Geneva] (GAP-Biophotonics), Group of Applied Physics [Geneva] (GAP), University of Geneva [Switzerland]-University of Geneva [Switzerland], Laboratoire SYstèmes et Matériaux pour la MEcatronique (SYMME), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Ecole Polytechnique Fédérale de Lausanne (EPFL), University of Geneva [Switzerland], Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( EA 3920) (PCVP / CARDIO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Nanothermometry General Physics and Astronomy Nanoparticle Gadolinium 02 engineering and technology Dielectric ddc:500.2 Upconversion nanoparticles 010402 general chemistry 01 natural sciences Fluorides chemistry.chemical_compound medicine Humans High harmonic generation General Materials Science Cell damage ComputingMilieux_MISCELLANEOUS Bismuth ferrite Photoinduced cell damage Harmonic generation business.industry General Engineering Silicon Dioxide 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Wavelength chemistry Harmonic [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic Nanoparticles Optoelectronics Harmonic nanoparticles 0210 nano-technology business Decoupling (electronics) |
| Zdroj: | ACS Nano (2020) ACS Nano ACS Nano, American Chemical Society, 2020, 14 (4), pp.4087-4095. ⟨10.1021/acsnano.9b08813⟩ |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/acsnano.9b08813⟩ |
| Popis: | We introduce a nonlinear all-optical theranostics protocol based on the excitation wavelength decoupling between imaging and photoinduced damage of human cancer cells labeled by bismuth ferrite (BFO) harmonic nanoparticles (HNPs). To characterize the damage process, we rely on a scheme for in situ temperature monitoring based on upconversion nanoparticles: by spectrally resolving the emission of silica coated NaGdF4:Yb3+/Er3+ nanoparticles in close vicinity of a BFO HNP, we show that the photointeraction upon NIR-I excitation at high irradiance is associated with a temperature increase >100 °C. The observed laser–cell interaction implies a permanent change of the BFO nonlinear optical properties, which can be used as a proxy to read out the outcome of a theranostics procedure combining imaging at 980 nm and selective cell damage at 830 nm. The approach has potential applications to monitor and treat lesions within NIR light penetration depth in tissues. |
| Databáze: | OpenAIRE |
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