Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex
| Autor: | James J. G. Wang, John R. Mascola, Rosanne Boyle, Ming Shen, Mary Salas, Chang Yi Wang, Marie Claire Gauduin, Lynette S. W. Sawyer, Richard A. Koup, Pei De Chen, Krishna K. Murthy, John Ye, Xinde Fang, Alan M Walfield, Wayne C. Koff, Ming Lie Li, David C. Montefiori, Carl V. Hanson |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Pan troglodytes medicine.drug_class medicine.medical_treatment T cell Mice SCID Viral Plaque Assay Simian Monoclonal antibody medicine.disease_cause Neutralization Mice Receptors HIV Neutralization Tests Leukocytes medicine Animals Humans Homosexuality Male Receptor Mice Inbred BALB C Multidisciplinary biology Antibodies Monoclonal virus diseases Immunotherapy Biological Sciences Simian immunodeficiency virus biology.organism_classification Virology medicine.anatomical_structure CD4 Antigens Immunology HIV-1 biology.protein Antibody |
| Zdroj: | Proceedings of the National Academy of Sciences. 96:10367-10372 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.96.18.10367 |
| Popis: | mAb B4 is a monoclonal antibody directed against HIV receptor complex. The antibody had broad neutralizing activity against HIV and provided postexposure prophylaxis to hu–peripheral blood leukocyte (PBL)–severe combined immunodeficient mice and chimpanzees. B4 recognized a complex receptor site for HIV on the T cell surface that includes CD4 and also may be influenced by interaction with HIV coreceptors. mAb B4 preferentially neutralized primary HIV-1 isolates compared with T cell line-adapted strains, including syncytium-inducing and non-syncytium-inducing phenotypes, representatives from HIV-1 subtypes A-G, as well as HIV-2, simian immunodeficiency virus, and chimeric simian/human immunodeficiency virus (SHIV). Neutralization was demonstrated in both pre- and postinfection models. The administration of mAb B4 after infectious challenge totally interrupted the infection of hu-PBL–severe combined immunodeficient mice by PBL-grown HIV-1 and the infection of chimpanzees by chimp-adapted HIV-1. This mode of protection suggested that the anti-HIV receptor antibody is efficacious for prophylaxis after exposure to HIV and for prevention of maternal transmission and may be an effective antiretroviral agent for treatment. |
| Databáze: | OpenAIRE |
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