The study of ischemia modified albumin as an early biomarker of epilepsy in adolescent population: a cross-sectional study
| Autor: | Anuj Sharma, Priyanka Asia, Ashok Kumar Ahirwar, Niranjan Gopal, Jyoti John, Seema Garg |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Adolescent Cross-sectional study Endocrinology Diabetes and Metabolism 030106 microbiology Ischemia Serum Albumin Human Non epileptic 03 medical and health sciences Epilepsy 0302 clinical medicine Endocrinology Internal medicine medicine Humans Molecular Biology business.industry Ischemia-modified albumin General Medicine medicine.disease Adolescent population Cross-Sectional Studies Early Diagnosis Biomarker (medicine) Female Epileptic seizure medicine.symptom business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Hormone Molecular Biology and Clinical Investigation. 42:183-187 |
| ISSN: | 1868-1891 1868-1883 |
| Popis: | Objectives Epilepsy is one of the most common neurological disorders, diagnosis of which is challenging as many unrelated conditions may mimic seizure. Epilepsy impairs the quality of life of patients due to associated physical and psychological trauma. Epileptic patients are also at increased risk of premature death due to autonomic disturbance and fatal accidents. The aim of the present research work was to study ischemia modified albumin (IMA) as an early biomarker of epilepsy in the adolescent population. Methods Twenty-five diagnosed cases of epilepsy and 25 healthy volunteers as control of adolescent group were recruited as study subjects. The study subjects were age and sex matched. Clinical evaluation, routine biochemical parameters and IMA estimation were carried out. Serum IMA was measured by spectrophotometric method. Results The mean serum IMA levels were significantly raised in epileptic patients (0.69 ± 0.1 absorbance units [ABSU]) as compared to the healthy control group (0.52 ± 0.24 ABSU) (p=0.004). ROC curve of IMA predicted that at cut off of 0.59 ABSU, the IMA has 96% sensitivity and 52% specificity for diagnosing epilepsy. Conclusions IMA may be used as a biomarker for early diagnosis of epilepsy as well as to differentiate epileptic seizure from various non epileptic disorders in the adolescent population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|