Assessment of iodohexadecenoic acid as a tracer of fatty acid metabolism by external detection: a study on isolated rat heart
| Autor: | F. Dubois, J.P. Mathieu, Xavier Leverve, D.S.Marti Batlle, C. Pernin, C. Keriel, Michel Comet, P. Cuchet |
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| Přispěvatelé: | Laboratoire de Physiologie Cellulaire Cardiaque, Université Joseph Fourier - Grenoble 1 (UJF), Laboratoire d'Etudes des Radiopharmaceutiques, Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Thérapeutique, Hamant, Sarah |
| Rok vydání: | 1992 |
| Předmět: |
MESH: Myocardium
MESH: Rats Cardiac metabolism Myocardial Reperfusion Palmitic Acids In Vitro Techniques Biology Models Biological 030218 nuclear medicine & medical imaging Iodine Radioisotopes 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Heart Rate TRACER parasitic diseases MESH: Myocardial Reperfusion Animals MESH: Animals MESH: Heart Rate MESH: Mathematical Computing Mathematical Computing 030304 developmental biology 0303 health sciences Fatty acid metabolism Myocardial metabolism Myocardium MESH: Palmitic Acids Fatty Acids MESH: Models Biological Rats Inbred Strains MESH: Iodine Radioisotopes General Medicine Rat heart Metabolism MESH: Rats Inbred Strains Rats MESH: Fatty Acids body regions Biochemistry chemistry Female MESH: Female Intracellular |
| Zdroj: | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, Elsevier, 1992, 19 (3), pp.349-55 International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1992, 19 (3), pp.349-55 |
| ISSN: | 0883-2897 |
| Popis: | International audience; Labelled fatty acids have been proposed to explore cardiac metabolism. For the analysis of the external detection curve obtained with 16-iodo 9-hexadecenoic acid (IHA), we developed a mathematical 4-compartment model with compartments 0, 1, 2 and 3 representing vascular IHA, intracellular IHA, esterified forms and iodide, respectively. This model, used here for isolated rat hearts perfused in a recirculating system, is validated by an intracellular analysis, then tested in various metabolic conditions. Thus, the mathematical analysis of the external detection curve gives us numerical data on IHA metabolism, especially the distribution between degradation and storage. Our results confirm the suitability of IHA for assessing myocardial metabolism. |
| Databáze: | OpenAIRE |
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