A mathematical model of cardiovascular dynamics for the diagnosis and prognosis of hemorrhagic shock
| Autor: | Lilach Gavish, Alessandro Borri, Laura D'Orsi, Arik Eisenkraft, Andrea De Gaetano, Luciano Curcio, Fabio Cibella |
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| Přispěvatelé: | D'Orsi, Laura, Curcio, Luciano, Cibella, Fabio, Borri, Alessandro, Gavish, Lilach, Eisenkraft, Arik, De Gaetano, Andrea |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cardiac output Mean arterial pressure Shock Hemorrhagic Settore ING-INF/01 - Elettronica Cardiovascular System General Biochemistry Genetics and Molecular Biology cardiovascular dynamics hemorrhagic shock Heart Rate Internal medicine Heart rate medicine Quantitative assessment Animals mathematical modelling Cardiac Output General Environmental Science Pharmacology General Immunology and Microbiology Mathematical model business.industry Applied Mathematics General Neuroscience Settore ING-IND/34 - Bioingegneria Industriale Experimental data General Medicine Models Theoretical Blood pressure Modeling and Simulation Settore ING-INF/06 - Bioingegneria Elettronica E Informatica Hemorrhagic shock Cardiology business |
| Zdroj: | Mathematical medicine and biology (2021). doi:10.1093/imammb/dqab011 info:cnr-pdr/source/autori:D'Orsi L; Curcio L; Cibella F; Borri A; Gavish L; Eisenkraft A; De Gaetano A;/titolo:A mathematical model of cardiovascular dynamics for the diagnosis and prognosis of hemorrhagic shock/doi:10.1093%2Fimammb%2Fdqab011/rivista:Mathematical medicine and biology (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| ISSN: | 1477-8602 1477-8599 |
| DOI: | 10.1093/imammb/dqab011 |
| Popis: | A variety of mathematical models of the cardiovascular system have been suggested over several years in order to describe the time-course of a series of physiological variables (i.e. heart rate, cardiac output, arterial pressure) relevant for the compensation mechanisms to perturbations, such as severe haemorrhage. The current study provides a simple but realistic mathematical description of cardiovascular dynamics that may be useful in the assessment and prognosis of hemorrhagic shock. The present work proposes a first version of a differential-algebraic equations model, the model dynamical ODE model for haemorrhage (dODEg). The model consists of 10 differential and 14 algebraic equations, incorporating 61 model parameters. This model is capable of replicating the changes in heart rate, mean arterial pressure and cardiac output after the onset of bleeding observed in four experimental animal preparations and fits well to the experimental data. By predicting the time-course of the physiological response after haemorrhage, the dODEg model presented here may be of significant value for the quantitative assessment of conventional or novel therapeutic regimens. The model may be applied to the prediction of survivability and to the determination of the urgency of evacuation towards definitive surgical treatment in the operational setting. |
| Databáze: | OpenAIRE |
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