Development of Silicone Rubber Hollow Fiber Membrane Oxygenator for ECMO
| Autor: | Masaki Kawamura, Daniel Oestmann, Yoichiro Kawaguchi, Shiniji Kawahito, Koshiro Sato, Toshiyuki Shinohara, Tomohiro Maeda, Hiroshi Ishitoya, Tadashi Motomura, Takahiro Matsui, Yukihiko Nosé, Julie Glueck, Seiji Ichikawa, Deborah Taylor |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Materials science medicine.medical_treatment Biomedical Engineering Medicine (miscellaneous) Plasma leakage Bioengineering Silicone rubber Biomaterials Hemoglobins chemistry.chemical_compound Extracorporeal Membrane Oxygenation Silicone Materials Testing Extracorporeal membrane oxygenation medicine Animals Oxygenator Oxygenators Membrane technology industry and agriculture General Medicine Centrifugal pump Surgery surgical procedures operative Membrane chemistry Hollow fiber membrane Silicone Elastomers Cattle Biomedical engineering |
| Zdroj: | Artificial Organs. 27:1050-1053 |
| ISSN: | 1525-1594 0160-564X |
| Popis: | Silicone rubber hollow fiber membrane produces an ideal gas exchange for long-term ECMO due to nonporous characteristics. The extracapillary type silicone rubber ECMO oxygenator having an ultrathin hollow fiber membrane was developed for pediatric application. The test modules were compared to conventional silicone coil-type ECMO modules. In vitro experiments demonstrated a higher O2 and CO2 transfer rate, lower blood flow resistance, and less hemolysis than the conventional silicone coil-type modules. This oxygenator was combined with the Gyro C1E3 centrifugal pump, and three ex vivo experiments were conducted to simulate pediatric V-A ECMO condition. Four day and 6 day experiments were conducted in cases 1 and 2, respectively. Case 3 was a long-term experiment up to 2 weeks. No plasma leakage and stable gas performances were achieved. The plasma free hemoglobin was maintained within a normal range. This compact pump-oxygenator system in conjunction with the Gyro C1E3 centrifugal pump has potential for a hybrid total ECMO system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text